Type 3b diabetes involves defects in the exocrine pancreas.

Type 3b diabetes involves defects in the exocrine pancreas.

• A. True
• B. False
• C. It involves beta cells
• D. It is MODY

Answer: (A)

Diabetes labeled as Type 3b (pancreatogenic) comes from disease of the exocrine pancreas that damages pancreatic tissue and, with it, the endocrine islets. When the exocrine pancreas is damaged by conditions such as chronic pancreatitis, pancreatic surgery, or pancreatic cancer, the loss or dysfunction of insulin-secreting cells follows, leading to diabetes. That makes the statement true: the condition involves defects in the exocrine pancreas, with the endocrine problem emerging secondarily from that exocrine damage. In contrast, diabetes driven by autoimmune destruction of beta cells (Type 1) or by monogenic beta-cell defects (MODY) hinges on primary beta-cell issues, not exocrine pancreatic disease, which is why those other options don’t fit.

Diabetes labeled as Type 3b (pancreatogenic) comes from disease of the exocrine pancreas that damages pancreatic tissue and, with it, the endocrine islets. When the exocrine pancreas is damaged by conditions such as chronic pancreatitis, pancreatic surgery, or pancreatic cancer, the loss or dysfunction of insulin-secreting cells follows, leading to diabetes. That makes the statement true: the condition involves defects in the exocrine pancreas, with the endocrine problem emerging secondarily from that exocrine damage.

In contrast, diabetes driven by autoimmune destruction of beta cells (Type 1) or by monogenic beta-cell defects (MODY) hinges on primary beta-cell issues, not exocrine pancreatic disease, which is why those other options don’t fit.