Which Fredrickson Type represents Primary Triglyceridemia or Familial Endogenous Triglyceridemia (VLDL) with high TAG?

Which Fredrickson Type represents Primary Triglyceridemia or Familial Endogenous Triglyceridemia (VLDL) with high TAG?

• A. Type I
• B. Type IIa
• C. Type III
• D. Type IV

Answer: (D)

The pattern being tested is how different lipoprotein elevations define a Fredrickson type. Primary or endogenous hypertriglyceridemia means the problem is excess VLDL produced by the liver, leading to high triglycerides with little or no increase in chylomicrons in the fasting state. In this type, the key feature is elevated VLDL causing elevated triglycerides while cholesterol may be normal or only mildly elevated. This is known as the endogenous hypertriglyceridemia pattern, where VLDL is predominant and chylomicrons are not elevated in fasting plasma. That fits best with the description of familial endogenous triglyceridemia (VLDL) because the VLDL particles are the main carrier driving the high triglyceride levels, rather than isolated elevation of LDL or accumulation of chylomicrons. Other patterns involve dominant elevations of chylomicrons (and possibly VLDL) or elevations of LDL remnants and cholesterol, which is not the case here.

The pattern being tested is how different lipoprotein elevations define a Fredrickson type. Primary or endogenous hypertriglyceridemia means the problem is excess VLDL produced by the liver, leading to high triglycerides with little or no increase in chylomicrons in the fasting state.

In this type, the key feature is elevated VLDL causing elevated triglycerides while cholesterol may be normal or only mildly elevated. This is known as the endogenous hypertriglyceridemia pattern, where VLDL is predominant and chylomicrons are not elevated in fasting plasma.

That fits best with the description of familial endogenous triglyceridemia (VLDL) because the VLDL particles are the main carrier driving the high triglyceride levels, rather than isolated elevation of LDL or accumulation of chylomicrons. Other patterns involve dominant elevations of chylomicrons (and possibly VLDL) or elevations of LDL remnants and cholesterol, which is not the case here.