Which statement best aligns with the material regarding insulin?

Which statement best aligns with the material regarding insulin?

• A. It promotes glycolysis.
• B. It inhibits glycolysis.
• C. It has no effect on cellular uptake.
• D. It reduces glycogen synthesis.

Answer: (A)

Insulin’s main action after a meal is to move glucose from the blood into tissues and steer it toward storage and utilization. It does this by increasing glucose uptake in insulin-sensitive tissues (like muscle and adipose) through GLUT4 translocation, and by promoting glycolysis to quickly convert glucose into usable energy. In the glycolytic pathway, insulin signaling raises the activity of key steps, notably by increasing fructose-2,6-bisphosphate levels via PFK-2, which activates PFK-1 and drives glucose through glycolysis. This helps generate ATP and provides intermediates for other stores and biosynthetic processes. At the same time, insulin promotes glycogen synthesis by activating glycogen synthase, so it does not reduce glycogen production. So the statement that insulin promotes glycolysis best aligns with its role in facilitating glucose uptake and its push toward glucose utilization through glycolytic processing.

Insulin’s main action after a meal is to move glucose from the blood into tissues and steer it toward storage and utilization. It does this by increasing glucose uptake in insulin-sensitive tissues (like muscle and adipose) through GLUT4 translocation, and by promoting glycolysis to quickly convert glucose into usable energy.

In the glycolytic pathway, insulin signaling raises the activity of key steps, notably by increasing fructose-2,6-bisphosphate levels via PFK-2, which activates PFK-1 and drives glucose through glycolysis. This helps generate ATP and provides intermediates for other stores and biosynthetic processes. At the same time, insulin promotes glycogen synthesis by activating glycogen synthase, so it does not reduce glycogen production.

So the statement that insulin promotes glycolysis best aligns with its role in facilitating glucose uptake and its push toward glucose utilization through glycolytic processing.