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Clinical Chemistry Numericals Practice Test

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  • Which ALP isoenzyme is most resistant to heating at 65°C for 30 minutes?
  • One consequence of squeezing the puncture site during collection is which of the following?
  • Which chemical inhibitor inhibits Bone and Liver isoenzymes?
  • Which of the following is NOT listed as a use of fluorometers in the source material?
  • Which analyte commonly requires anaerobic transport to preserve its measured value?
  • Which odor is characteristic of cyanide exposure?
  • Which statement correctly describes lactic acidosis types?
  • In the sodium level table, which condition is associated with high sodium?
  • In assessing CRP for CHD and stroke risk, how should samples be measured?
  • Which is a continuum light source?
  • What is the most common treatment for Conn's syndrome?
  • Which ion activates creatine kinase as an enzyme cofactor?
  • In salting-out albumin procedure, high salt precipitates which fraction?
  • Which statement is true about acid strength and pKa in relation to strong and weak acids?
  • Normal BUN-to-creatinine ratio but with elevated BUN and creatinine suggests which state?
  • Which lipid parameter is commonly measured in a basal fasting lipid panel?
  • Which tissue responds to oxytocin to promote lactation?
  • Which term describes the relationship of one quantity to another by division?
  • Which units are used for reporting creatinine in blood and in urine?
  • What is the titrant used in the method?
  • Ideal storage temperature for enzymes is typically:
  • In Tyrosinemia Type II, deficiency of which enzyme?
  • In a pH electrode, what is the typical material used for the measuring electrode's covering membrane?
  • Which two gonadotropins are most commonly assessed together as part of fertility evaluation?
  • In electrophoresis isoenzyme numbering, which isoenzyme is the fastest migrating?
  • Elevation of alkaline phosphatase in obstructive bile duct obstruction is typically how many times ULN?
  • In the 'Countercurrent' concept for chloride, which ion is listed?
  • What is the conversion factor between International Units (IU) and nano katal (nkat)?
  • Which organ is the first affected during hypoglycemia?
  • What is the purpose of adding LDH to the Walker/Karmen reagents?
  • Which BAC range corresponds to the euphoria stage?
  • Calcium and lithium ions in ion-selective electrodes use which type of membrane?
  • In hyperlipoproteinemia with high VLDL, which plasma appearance is typical?
  • Which female hormone is present in males?
  • Which drug is nephrotoxic and ototoxic?
  • Which apolipoprotein serves as a surrogate marker for HDL?
  • Which method is enzymatic (GLDH) for ammonia determination?
  • Pipets by Design differentiate contain vs deliver. Which term corresponds to deliver?
  • Verapamil belongs to which class of antiarrhythmic drugs?
  • Which substrate is associated with the King-Armstrong method for alkaline phosphatase measurement?
  • Kasha disease is a deficiency of which trace element?
  • Delta checks in laboratory data are used to detect discrepancies between current and prior results in which two error categories?
  • Measured osmolality minus calculated osmolality is called what?
  • Which term is one of the 5S principles in Lean manufacturing?
  • What percentage of serum calcium is protein-bound?
  • Which enzyme category is known for introducing or removing double bonds (creating double bonds)?
  • In the Walker/Karmen method for AST determination, which substrate is used by the enzyme (MDH)?
  • Which condition shows TSH normal, FT4 normal, TT3/TT4 low, and T3 uptake high due to low thyroid-binding globulin?
  • Which two vessels supply the liver?
  • Which electrolytes are designated for myocardial rhythm and neuromuscular excitability?
  • Which bands are included in the general APR classification?
  • Which apolipoprotein is predominantly distributed in HDL, chylomicrons, and acts as a LCAT activator?
  • Which stage comes after euphoria in the ethanol impairment sequence?
  • Which of the following is an example of a precipitating media used in HDL-C methods?
  • Bisalbuminemia can lead to which clinical implication?
  • Secondary hypergonadism is most commonly due to what?
  • The measuring electrode covering membrane for a pCO2 electrode is typically which material?
  • In hereditary hemochromatosis, which pattern is expected on an iron panel?
  • Euthyroid Sick Syndrome is also known as what?
  • Total immersion calibration applies to which equipment?
  • During the follicular phase of the menstrual cycle, which sequence occurs?
  • Which enzyme is required to break down the muscle relaxants succinylcholine and mivacurium?
  • Which HbA1c method is described as the preferred method for measurement?
  • In assay terminology, what describes the Endpoint measurement?
  • Isopropanol can be metabolized to which compound?
  • Which dye is used to stain lipoproteins?
  • What is the normal anion gap range without including potassium?
  • What creatinine value indicates completeness of a 24-hour urine collection?
  • Thyrotoxicosis is associated with exposure to which trace element?
  • Gradual loss of albumin is most associated with which condition?
  • What does PAGE stand for in electrophoresis terminology?
  • Which of the following is an essential amino acid?
  • To convert percent w/v to molarity for a substance with molecular weight MW, which formula gives M?
  • For UV and visible light measurements, which material is commonly used for sample cells?
  • Which bilirubin form has higher CNS affinity, increasing the risk of kernicterus?
  • What is the DPMO (defects per million opportunities) for Six Sigma?
  • Which LD measurement method is faster?
  • Which Fredrickson Type represents Primary Triglyceridemia or Familial Endogenous Triglyceridemia (VLDL) with high TAG?
  • Which of the following is NOT a method of bilirubin determination?
  • GGT is often elevated more than tenfold in which condition?
  • Which Fredrickson Type corresponds to familial hypercholesterolemia due to LDL receptor defect (high LDL and total cholesterol)?
  • Which liver function is affected last as hepatitis progresses?
  • In the condensation method, what color indicates formation of Schiff's base with glucose?
  • What is the reference range for globulin in serum?
  • In the D/L designation, the D form corresponds to the OH group on the penultimate carbon pointing to the:
  • In ABG analysis, a bicarbonate/carbonic acid ratio of less than 20:1 indicates:
  • Which is an indication for arterial puncture?
  • Which metal is associated with destruction of type 1 alveolar epithelial cells in the lungs and increased resistance to certain bacterial infections?
  • Which component is added by a Comprehensive Panel that is not part of the Basic Metabolic Panel?
  • Which pattern on electrophoresis indicates an acute inflammation/ Immediate response pattern?
  • What are two common methods for measuring enzyme activity?
  • In progressive liver disease, which hepatic function tends to decline last?
  • In the CK-coupled enzymatic method, which cofactor is used in the final reaction and measured by UV spectrophotometry?
  • Molarity is defined as
  • Which diffusion-based ammonia measurement method uses a membrane containing nonactin/monactin?
  • Gestational diabetes insipidus is caused by increased activity of which enzyme?
  • Which metabolite is the end product of dopamine metabolism?
  • A prediabetes risk factor includes a body mass index of 25 kg/m2 or higher.
  • Which Fredrickson Type corresponds to Mixed Hyperlipidemia (CM and VLDL)?
  • Which hormones are commonly tested in infertility workup?
  • Lucey-Driscoll Syndrome is due to which mechanism?
  • Which two markers are used to diagnose insulinoma?
  • What is the reference method for lipoprotein analysis?
  • LD6 (Alcohol dehydrogenase) is associated with which condition?
  • The GLDH-coupled method for ammonia determination uses which cofactor with glutamate?
  • Which apolipoprotein’s function includes acting as an LPL cofactor?
  • Marker for bone formation
  • A protein composed of more than one polypeptide chain held together by non-covalent interactions has which level of structure?
  • Cushing's syndrome is also known as hyperadrenalism because it affects which adrenal zones?
  • Which analyte is typically decreased in a hemolyzed sample?
  • Which sequence correctly expands the PDCA cycle?
  • Which hormone from the anterior pituitary stimulates milk production?
  • For secondary adrenal insufficiency, which stimulation test is used as a screening test?
  • Which pair of diseases is associated with alpha-1 antitrypsin deficiency?
  • What total cholesterol value is considered Desirable according to reference ranges?
  • Rochelle's salt is another name for which compound?
  • What is the critical range for calcium?
  • Polyclonal gammopathy with large elevation in gamma and beta-gamma bridging due to IgA is most characteristic of which condition?
  • Which test is used mainly for monitoring long-term glycemic control?
  • What is the NCEP goal for HDL cholesterol?
  • RAUI measures thyroidal uptake of iodine after an oral dose of which isotope?
  • Which of the following is an action of Angiotensin II?
  • The De Ritis ratio represents the relative activities of which two liver enzymes?
  • Which statement accurately describes the Tanzer-Gilvarg CK determination method?
  • How is the Therapeutic Index calculated?
  • Growth hormone (GH) has which metabolic effects?
  • Which of the following is NOT among the three most osmotically active particles in serum?
  • Which marker is used to differentiate benign prostatic hyperplasia (BPH) from prostatic carcinoma (PC)?
  • Which condition is a common cause of persistent hypoglycemia?
  • High-resolution protein electrophoresis separates proteins into how many bands?
  • C-peptide levels are high in which condition?
  • The endpoint of the titration corresponds to the formation of which fatty acid?
  • Which statement describes the direct method for osmometry?
  • Two types of hypoglycemia and hours?
  • Which photodetector is described as the most common and most sensitive for low light levels?
  • What is the reference range for TSH?
  • Ammonia is reported in which unit, distinguishing it from other NPN measurements?
  • Which method is colorimetric for potassium measurement?
  • Enzymes with the same catalytic activity but different structures are called what?
  • Which of the following is an example of a proliferation signal inhibitor?
  • For impedance method of aspirin analysis, which anticoagulant is recommended?
  • What is the reference range for fructosamine in umol/L?
  • Base ideal body weight used in Cockcroft-Gault for male and female before height adjustments is?
  • Which term indicates the concentration change resulting from dilution with solvent?
  • Which lipoprotein has the lowest cholesterol content?
  • Which substrate is characteristic for alkaline phosphatase (ALP) in luminescent assays?
  • ApoB48 main distribution and function?
  • Which term describes the process of verifying an initial result?
  • A spike of alpha-2 macroglobulin (A2) is most characteristic of which condition?
  • Which condition corresponds to Cushing's syndrome due to autonomous adrenal cortisol production?
  • Which term describes 'Any test on any sample at any sequence' in automation?
  • Neonatal Hyperbilirubinemia is due to which condition?
  • For the sample type used in evaluating hemolysis effects, which is preferred?
  • Which Fredrickson type is most common?
  • What fasting period is recommended before triglyceride measurement?
  • What percentage of cholesterol is endogenous (liver) according to the material?
  • Which pipet category does not require calibration?
  • The T-test formula described uses the difference between means as its numerator. Which expression represents this?
  • Which hormone is increased in primary hypothyroidism and decreased in primary hyperthyroidism?
  • Conjugated proteins are composed of an apoprotein and what non-protein component?
  • Which rpm falls within the cytocentrifuge speed range of 200-1000 rpm?
  • Which of the following lists the two methods of lactate determination described?
  • What is the silicate concentration for Type 2 reagent water?
  • Which option is NOT one of the three basic automation approaches?
  • If 10% contamination with 5% dextrose occurs, the glucose reading can increase by how many mg/dL?
  • What is the normal reference range for serum albumin?
  • Secondary bile acids include which?
  • In the provided notes, Six Sigma is applied to achieve what?
  • If K2EDTA is collected before serum or a light-blue tube, which tests are erroneous?
  • Which component is part of the surface of lipoproteins?
  • What is the first step in cerebrospinal fluid (CSF) analysis?
  • Levels of standards are described as which set?
  • What are the reference ranges for total CK for men and women respectively?
  • Which condition is a known stimulant of growth hormone secretion?
  • Which process cycle is used in Six Sigma methodology?
  • Which tumor is associated with increased VMA and HVA due to dopamine involvement?
  • What is the most common cause of secondary hyperaldosteronism?
  • Which statement correctly describes reflectance photometry?
  • Which of the following is a substrate for horseradish peroxidase (HRP) in luminescent assays?
  • Which distribution accurately describes magnesium in plasma?
  • Which factor can cause a false positive blood bhCG result?
  • With a 1°C rise, pCO2 changes by which percent?
  • In spectrophotometers, which dispersive element provides linear wavelength dispersion?
  • Coagulation QC is performed with how many levels and how often?
  • Which marker best reflects hepatic synthetic function?
  • Ion selective electrodes have largely replaced which instrument?
  • Which equation correctly estimates TIBC in ug/dL from transferrin measured in mg/dL?
  • CK-MV is less than 6% and is associated with which CK isoenzyme?
  • Which lipoprotein density is less than 0.93?
  • Renal tubular acidosis typically presents with which acid-base disturbance and chloride status?
  • DPMO is most commonly associated with which quality framework?
  • Which of the following is a planar chromatography method?
  • Which statement correctly describes Arrhenius acid-base theory?
  • The MDRD equation for estimating GFR uses which variables?
  • What is the formula for percent transferrin saturation?
  • A Poor SDI (Sigma Deviation Index) is indicated when SDI value exceeds what threshold?
  • What is the preferred sitting time for cholesterol testing?
  • A photodetector converts energy from which form to electrical energy?
  • Arsenic has high affinity for which tissue, used for long-term exposure assessment?
  • Euthyroid with high TBG occurs in which situations?
  • Which statement is true about HbA1c testing methods based on the provided notes?
  • What is the difference called between calculated osmolality and measured osmolality?
  • Which apolipoprotein acts as an inhibitor of lipoprotein lipase (LPL)?
  • Derived formula of molarity is equal to
  • In flame photometry, which statement is true?
  • Which statement about calcium distribution is true?
  • For artifactual or pseudohyperkalemia, which factor is a common laboratory cause?
  • A perfect Gaussian (normal) distribution occurs when which measures of central tendency are equal?
  • Which plastic is autoclavable primarily for chemical resistance?
  • What is the prohormone of thyroglobulin?
  • Hypotension in Addison's disease is primarily due to deficiency of which adrenal hormone?
  • Abetalipoproteinemia is caused by a mutation in which gene and results in absence of B-100 and B-48?
  • In the standing plasma test, which finding indicates the presence of chylomicrons?
  • Which LD isoenzymes decrease when stored at 4°C?
  • Which of the following is a correct pairing described in the notes?
  • In Cushing's disease, what is the pattern for plasma cortisol, ACTH, and response to high-dose dexamethasone suppression test?
  • Which type of bond predominates in the secondary structure of proteins?
  • What is the reference range for urine amylase?
  • Gestational DI is caused by which mechanism?
  • A flat gamma curve on serum protein electrophoresis is most closely associated with which condition?
  • Which electrolytes are designated for volume and osmotic regulation?
  • Which glass is low thermal resistance and suitable for strong acids and alkali?
  • What is the peak time after intravenous administration for digoxin?
  • Hyperglycemic hormones are released at what plasma glucose level?
  • Which term describes results used as legal evidence?
  • Which test provides an indirect measure of thyroxine-binding globulin (TBG)?
  • If a compound has molecular weight 180 and valence 3, its equivalent weight is
  • Which speed value is exactly at the upper limit of 200-1000 rpm?
  • Which statement correctly describes catecholamines (tyrosine-derived amines) in terms of solubility and half-life?
  • When should neonatal screening for congenital hypothyroidism be performed?
  • Which item is NOT listed as an important component of a fluorometer?
  • In target therapy for high-risk patients, which lipid parameter should be optimized?
  • Panic values of hypoglycemia are defined as which plasma glucose levels?
  • Which HDL-C value is considered Desirable?
  • In the Reinsch test, which color indicates arsenic?
  • Which four components constitute the standard electrolyte panel plus a bicarbonate that is calculated?
  • What is the standard path length of a cuvet in most spectrophotometers?
  • In TLC, the retention factor (Rf) is calculated as which ratio?
  • Severe vomiting and severe burns are associated with what change in chloride levels?
  • Riboflavin (Vitamin B2) deficiency commonly presents with which symptoms?
  • Apoenzyme plus a prosthetic group forms which enzyme type?
  • In LDL homogeneous assay, which two reagents are used and what are their roles?
  • Which tumor increases AFP only?
  • The Joint Commission requires laboratories to be accredited by how many organizations?
  • Conn's syndrome is another name for which disorder?
  • Renal tubular acidosis affects chloride by causing:
  • Which instrument is used to measure NADPH in the reference method?
  • If solute volume is 4 mL and total volume is 20 mL, the dilution factor D equals
  • Which two hypothalamic nuclei store hormones released by the posterior pituitary?
  • Which method is a colorimetric method for chloride determination?
  • Which condition would increase the ionized fraction of calcium?
  • Which statement correctly defines Positive Predictive Value?
  • Which method is used for phosphate determination as described?
  • Which protein is NOT listed as one of the alpha-1 globulins in the material?
  • What is the angle range for arterial puncture at radial and brachial sites?
  • Which calcium measurement method is categorized as colorimetric?
  • The colloid inside thyroid follicles is primarily composed of which protein?
  • In electrophoresis scatter, which pattern is associated with large particles?
  • Which reaction type characterizes the Oliver-Rosalki CK determination method?
  • HbA1c testing should be repeated every how many months for patients noncompliant with targets?
  • What is the pH of the reaction in the Evelyn-Malloy method?
  • Which metals can cross the placenta?
  • The Van de Berg modification of Ehrlich reagent adds what to the reaction as an accelerator?
  • Which of the following is a storage function of the liver?
  • What is the reference method for therapeutic drug monitoring (TDM) and HbA1c measurement?
  • Which item is included in RECSQ analytical elements?
  • Which analyte is commonly preserved by chilling the sample immediately after collection?
  • Which lipoprotein density range is 1.006 to 1.019?
  • Which of the following are examples of automation systems?
  • What are the two calibration methods for micropipettors?
  • What is the primary purpose of antiglycolytic agents in blood specimens used for glucose testing?
  • Which protein is associated with obesity as a marker in the material?
  • Which ISO standard applies to clinical laboratories?
  • Using the transmittance formula T(%) = 10^(2 - A), what is the transmittance when absorbance A equals 0?
  • A noticeable error in indirect LDL estimation occurs when TAG exceeds what value?
  • Which statement correctly describes the percent liver damage for hepatitis and cirrhosis?
  • ApoA1 main distribution and function?
  • Which hormone is a regulator of calcium in the body?
  • Which condition is caused by defective copper reabsorption leading to low copper levels?
  • Which pairing correctly matches a cardioactive drug with its common indication?
  • Which immunoassay for thyroxine testing corresponds to a microparticle EIA with an ELISA sandwich format?
  • Panic values for pH are at which level(s)?
  • Symptoms beginning of hypoglycemia occurs at which plasma glucose level?
  • In the Walker/Karmen method for ALT determination, which substrate is used by the enzyme?
  • The smallest endocrine gland secretes which hormone?
  • Which foods are listed as BVCT (Banana, Vanilla, Coffee, Tea) affecting VMA/HMMA testing?
  • TBG levels depend on the levels of which substance?
  • Uric acid is a product of catabolism of which purines?
  • In cirrhosis, which laboratory pattern is typical?
  • In addition to chloride, which anion serves as an enzyme activator?
  • How is prostatic ACP calculated?
  • Which two drugs induce GGT?
  • Which statement best describes the three requirements for a standard curve?
  • In the context of reference interval vs reportable range, which statement is correct about the reportable range?
  • What are the two broad categories of ammonia determination methods described?
  • Which amylase method is described as Saccharogenic and expressed in Somogyi units?
  • In the perfect correlation principle, what is the slope?
  • Which of the following are indications for capillary puncture?
  • Reference range for creatinine using the enzymatic method in females?
  • Which photodetector type requires no external voltage?
  • Which counter type is typically used for gamma-emitting isotopes like I-125 and I-131?
  • Which biochemical marker is used to assess bone resorption in osteoporosis?
  • How many times should all tubes be inverted in general?
  • Which is an example of relative hyperproteinemia?
  • What is the reference range for T3U?
  • Phosphate is usually measured as which form?
  • Which disease is primarily associated with elevated HVA and VMA in urine measured by HPLC?
  • In scintillation counting, a crystal gamma counter is used to detect gamma-emitting isotopes such as which of the following?
  • Which pair best describes electromagnetic radiation?
  • In congenital adrenal hyperplasia, what hormonal pattern is typically observed?
  • What is the reference range for the amylase:creatinine clearance ratio (SCUA)?
  • Which type of error affects accuracy?
  • Which laboratory value is used to monitor long-term glycemic control in diabetes?
  • Which analytes are falsely elevated in ECO anticoagulants?
  • Metal fume fever is most strongly associated with inhalation of fumes of which element?
  • Which statement correctly describes Bronsted-Lowry acid-base theory?
  • Modified Van Handel Zilversmith method modifications?
  • Capillary electrophoresis is best associated with which separation mechanism?
  • Which MS technique is commonly employed for IEM screening?
  • What is the most common cause of biliary obstruction?
  • Which specimen is appropriate for measuring inorganic phosphate given diurnal variation?
  • Which statement about T3 production is correct?
  • ACS Primary Standard purity level is typically what?
  • What is described as the most common quality management framework?
  • In the colorimetric chemical method, LB yields which color product?
  • For UV and IR spectral measurements, which material is commonly used for sample cells?
  • Which patient preparation is recommended for catecholamine testing?
  • Laboratory error described as increasing sodium and potassium while decreasing chloride and bicarbonate would cause which effect on the calculated anion gap?
  • What is the Diazo blank composition in the 3-diazo reagents setup?
  • Which pair of markers are used as the two natriuretic peptide markers for congestive heart failure?
  • Which mnemonic corresponds to 'magnesium in, calcium out'?
  • The abbreviation VMA refers to which compound?
  • Which particle carries the highest cholesterol content?
  • Calibration of the pO2 electrode requires which standard?
  • Which immunoassay type is heterogeneous and uses microparticles in a solid phase with enzyme-labeled antibodies?
  • In the Porter-Silber test for hydroxycorticosteroids, which reagent is used and what color is observed?
  • The upper limit value of the cytocentrifuge speed range is which of the following?
  • What is the color observed in the standard alkaline phosphatase colorimetric method?
  • Reye's syndrome is characterized by a threefold increase in which markers?
  • Which of the following is an example of a TC pipette?
  • In normal serum, which LD isoenzyme predominates?
  • In the synthesis of thyroid hormones, which component is produced first?
  • In Henderson-Hasselbalch relation for bicarbonate buffering, pH equals pKa plus log of which ratio?
  • For individuals with at least one risk factor, how often should screening be performed?
  • On semilogarithmic paper used in spectrophotometry, what is plotted on the y-axis?
  • Which equation correctly represents the Lineweaver-Burk plot for enzyme kinetics?
  • Which method for urea determination uses diacetyl monoxime (DAM) to produce a yellow diazine?
  • Electrophoretic mobility: which lipoprotein shows beta mobility?
  • The SI prefix corresponding to 10^2, as listed in the material, is which?
  • Which protein is NOT typically part of the alpha-2 globulin band in serum electrophoresis?
  • Which of the following is NOT listed as an early or late biomarker of AKI?
  • Which pressure primarily governs water movement between body compartments?
  • Triglycerides provide energy primarily through conversion to which molecule?
  • CRP levels: which range defines high risk for CHD/stroke?
  • Which are precipitation agents for protein turbidimetry?
  • Which enzyme catalyzes the iodination and coupling steps forming MIT/DIT and T3/T4 during thyroid hormone synthesis?
  • Which dye-binding reagent is most specific and precise for albumin measurement?
  • What is the SI unit of enzyme activity?
  • For individuals aged 45 with more than one risk factor, how often is screening recommended?
  • What pre-treatment step is required before electrophoresis for CSF and urine samples?
  • Ketonuria contributes to hyponatremia by which mechanism?
  • Approximately what percentage of testosterone is bound to albumin?
  • What is the principle behind most glucose point-of-care tests?
  • Which cell type is listed among liver tissue components as a non-parenchymal cell involved in extracellular matrix production?
  • Which biomarker is the earliest enzyme elevated in acute myocardial infarction?
  • Which condition involves tissue damage due to iron overload?
  • Which element is associated with Minamata disease (mercury poisoning)?
  • In ectopic Cushing syndrome, what is the pattern for cortisol, ACTH, and high-dose dexamethasone suppression test?
  • Which trisomy is NOT typically associated with decreased AFP in maternal screening?
  • Which of the following is a known contributor to hyperkalemia?
  • Which additive is commonly used to prevent glycolysis in samples for glucose testing?
  • Which electrophoresis pattern is associated with juvenile cirrhosis?
  • Which equation corresponds to the De Long method for estimating VLDL in mg/dL?
  • Dissolved CO2 in blood (H2CO3) is calculated as:
  • Which method for ethanol measurement is described as enzymatic?
  • Which BAC range corresponds to stupor?
  • The indirect pathway of HDL cholesterol return to the liver involves CETP-mediated exchange. Which option best describes this pathway?
  • Normal phase HPLC is characterized by what?
  • Which of the following is an enzyme commonly measured in clinical chemistry?
  • Which hormones are produced by the thyroid gland?
  • D and L enantiomers are based on which carbon's hydroxyl group?
  • Lead exposure can occur via which routes?
  • Which has about 10-40% carbohydrate content?
  • In electrophoresis, what term describes the movement of buffer ions and solvents within the support material?
  • Which item from the HARDASS mnemonic is a drug that can contribute to normal anion gap metabolic acidosis when given?
  • Which lipoprotein is the second most atherogenic?
  • Cushing's disease is listed as an additional cause of hypernatremia. Which of the following is another listed cause?
  • Pipets by Design differentiate contain vs deliver. Which term corresponds to contain?
  • Which particle has the highest triglyceride content?
  • In Nesslerization for ammonia, the reaction of ammonium with dipotassium mercuric iodide yields which color?
  • On a Lineweaver-Burk plot of 1/v versus 1/[S], what is the y-intercept?
  • The Krebs cycle yields how many ATP per acetyl-CoA under aerobic conditions?
  • What is the pH range for Type 3 reagent water?
  • In fluorescence polarization immunoassay, polarization is inversely related to the analyte concentration.
  • Which lipoprotein has the highest protein content?
  • Chemical storage should be organized according to which criterion?
  • Which lipoprotein density range is 0.93 to 1.006?
  • Decreased unmeasured cations, such as in hypocalcemia, would have what effect on the anion gap?
  • In a verification study of a reference interval with 20 subjects, how many results should fall within the interval for acceptability?
  • What percent of T4 is bound to albumin in circulation?
  • Which medium is used for separation by both size and charge in electrophoresis?
  • Which test is used as a screening test for primary hypercortisolism?
  • Which diagnostic test is used for confirming GDM, DM, and impaired glucose tolerance?
  • TC pipets are calibrated with which substance?
  • Which speed value is exactly at the lower limit of 200-1000 rpm?
  • What is a synonym for analytical sensitivity?
  • Mature alpha-HDL returns cholesterol to the liver via two pathways. Which statement correctly describes these pathways?
  • What is the defining feature of monoclonal gammopathy on electrophoresis?
  • Prehepatic conditions include which of the following?
  • Type 1a/1.5 is Latent Autoimmune Diabetes of Adulthood and is characterized by a single specific islet cell autoantibody.
  • Which lipoprotein has protein greater than cholesterol as its major component?
  • On linear graph paper in spectrophotometry, what is plotted on the y-axis?
  • Lead exposure inhibits which enzymes involved in heme synthesis?
  • What is the gold standard test for confirming growth hormone deficiency?
  • What was the earliest method used for bilirubin determination?
  • In the G6PD-based method, what spectrophotometric detection is used?
  • What instrument is used to measure rotor speed during centrifuge calibration?
  • Which of the following is NOT a Dye Lake dye?
  • What is the recommended lancet length for adults?
  • Which of the following is NOT a CHIMPS cause of hypercalcemia?
  • Macroenzymes have a higher half-life because they are less excreted in the urine. Which statement is true?
  • Which test is described as the SIADH diagnostic test in the material?
  • Which protein increases up to ten-fold in nephrotic syndrome?
  • What does Multipoint refer to in kinetic assays?
  • Panic values for pCO2 are at which values?
  • Normality can be expressed as which of the following?
  • For osmolality testing, which specimen is described as the best?
  • Increased renin production is typically associated with which initial blood pressure state?
  • Which measurement provides an estimate of glomerular filtration rate (GFR)?
  • What is the main driving force of the bicarbonate-carbonic acid buffering system?
  • Which of the following is not one of the nutritional status markers listed?
  • Jaundice is typically clinically apparent when bilirubin reaches what range?
  • What percentage of T3 is produced directly by the thyroid gland?
  • One example of secondary hyperuricemia is which condition?
  • Hypoprogesteronemia is associated with which outcome?
  • What is the maximum total error allowed for HDL-C measurements under NCEP guidelines?
  • In hyperlipoproteinemia, which plasma appearance is associated with high chylomicrons (CM)?
  • The SI prefix for 10^15 is which of the following?
  • Which of the following is a cause of hypokalemia due to gastrointestinal loss?
  • Which lipoprotein is categorized as beta-lipoprotein?
  • Which method is used for chloride determination according to Schales and Schales?
  • Which apolipoprotein serves as the remnant receptor ligand recognizing chylomicron and VLDL remnants for hepatic uptake?
  • Type 3a diabetes involves genetic defects for beta cells.
  • Which of the following is a naturally occurring opiate?
  • Which is listed as a function of proteins?
  • Approximately what percentage of testosterone is free in plasma?
  • In time-domain detection of a double-beam spectrophotometer, how many detectors and choppers are used?
  • Which marker is used to detect cerebrospinal fluid leakage?
  • Which term describes the migration of large ions in electrophoresis?
  • Which molecule is the other organic coenzyme listed besides NAD/NADH?
  • Blow-out (viscous) and Self-draining (non-viscous) describe which two pipette drainage characteristics, with BO and SD correspondences?
  • In CQI, which belt level corresponds to project sponsors?
  • In fulminant hepatic failure, which marker is disproportionately elevated relative to others?
  • Peak-level collection times for different administration routes are: IV after 30 minutes, IM after 60 minutes, Oral after 1-2 hours.
  • What is the formula for percent transmittance in spectrophotometry?
  • Which anticoagulant is used for enzyme testing?
  • The chorion is composed of which two layers?
  • FTI is a product of TT4 and which factor?
  • Which test is used as a screening test for primary adrenal insufficiency?
  • Which electrophoresis pattern corresponds to chronic infection with a delayed response?
  • Intestinal alkaline phosphatase is more commonly seen in secretors of which blood groups?
  • What is considered the gold standard biomarker for acute myocardial infarction?
  • In postmenopausal women, which estrogen predominates?
  • Which test is used as a confirmatory test for primary hyperaldosteronism?
  • The measurement of 1,5-anhydroglucitol is reported in which unit?
  • For which tube type is the inversion exception 5 times?
  • An LDL-C of 150 mg/dL falls into which category?
  • Transferrin is described as which type of protein?
  • Macroenzyme 2 is bound to what?
  • Which compound is primarily produced as an androgen by the adrenal cortex?
  • Which is the best indicator of precision in a laboratory measurement?
  • Neonatal jaundice is noted at how many days of life?
  • Andersen disease is due to deficiency of which enzyme?
  • Which equation represents Planck's formula relating energy to frequency?
  • Which enzyme is most specific for pancreatitis?
  • To diagnose diabetes, HbA1c must be at least what value on two occasions?
  • Enzyme denaturation is usually observed at which temperature range?
  • Which hormone is produced entirely within the thyroid gland?
  • Which method is described as a reference method for HbA1c testing?
  • What is the standard formula for percent transmittance in spectrophotometry?
  • Which of the following is a direct expression of Beer's Law relating absorbance to concentration and path length?
  • Which apolipoprotein is distributed in CM, VLDL, and HDL and has a structural role?
  • Which lipoprotein contains the highest phospholipid content?
  • Aluminosilicate glass is approximately how many times stronger than borosilicate glass?
  • Which dye-binding reagent is specific but interfered by hemolysis and bilirubin?
  • What is the first step in method evaluation?
  • Which of the following is a semi-synthetic opiate?
  • Which lipoprotein has exogenous triglycerides as its major component?
  • Increased breakdown of albumin is seen in which condition?
  • Which value represents the acceptable total error for triglyceride measurements under NCEP guidelines?
  • Which tissue is a primary target of oxytocin to induce labor?
  • Which enzyme releases free cholesterol from macrophages?
  • Uric acid deposition in tissues occurs when serum uric acid exceeds which threshold in mg/dL?
  • The measuring electrode tip for a pH electrode is commonly made of which material?
  • Congenital Minamata disease is caused by exposure to which metal?
  • What is the rpm range for a cytocentrifuge used for cell counts?
  • Plasma ACTH levels in ACTH-dependent Cushing syndrome are typically:
  • What is the ADA pre-prandial glucose goal?
  • If a blood sample is contaminated with intravenously infused fluids, which analyte is most likely to show an artificial increase?
  • Which test differentiates neurogenic DI and primary polydipsia from nephrogenic DI?
  • In the linear equation y = mx + b, what does b represent?
  • Which of the following is a major risk factor that modifies LDL goals?
  • Which pairing correctly matches an acid-base disorder with its major cause and compensation?
  • How long can refrigerated serum samples be stored before analysis?
  • Which automatic micropipettor operates like a hypodermic syringe for viscous samples with constant aspiration force?
  • Which bone houses the pituitary gland?
  • Inappropriate ACTH production refers to which condition?
  • If pseudocholinesterase is absent, what condition is expected?
  • Which is the most potent hallucinogen?
  • Cori disease (Type IIIa) is due to deficiency of which enzyme?
  • 130 mmol/L sodium is associated with the onset of hypokalemia due to renal threshold. Which option reflects this level?
  • Which defect is associated with Gilbert Syndrome among hepatic B1 diseases?
  • Appearance corresponding to triglyceride level around 350 mg/dL?
  • For catecholamine testing, which specimen type is described?
  • Which combination of hormones originates from the skin and liver respectively?
  • Which precaution should be avoided prior to collecting a sample for ammonia measurement?
  • It is the number of particles a molecule dissociates into when dissolved in a solvent.
  • In hyponatremia, plasma osmolality is typically:
  • Which is the correct formula for osmolality when concentrations are given in mg/dL?
  • For CVA collection, how much initial volume should be discarded?
  • Which ion acts as an activator of alkaline phosphatase?
  • Fructosamine is contraindicated in which condition?
  • In the measurement of Total Iron Binding Capacity (TIBC), what is the purpose of saturating transferrin with ferric iron?
  • Citrate tubes have an inversion exception of how many times?
  • Which compound is used to calculate bicarbonate in the anion gap calculation described?
  • What CRP level range defines low risk?
  • Reference range for creatinine using the Jaffe method in males?
  • Diagnostic test for galactosemia measures activity of which enzyme in erythrocytes?
  • Osmolality is calculated as Molarity multiplied by what factor?
  • Which two endogenous markers are used to estimate glomerular filtration rate?
  • Approximately how many primordial follicles are present in neonates?
  • Decreased creatinine clearance indicates which of the following?
  • Which are the three steps in iron determination from transferrin?
  • B-VLDL is seen in which hyperlipoproteinemia?
  • In Asia-Pacific BMI categories, obesity is defined as BMI greater than:
  • Which reagent is used in the colorimetric Jaffe method for creatinine determination?
  • What is the silicate concentration for Type 1 reagent water?
  • Which set of enzymes is involved in interconversion of mature alpha-HDL subspecies?
  • Which drug is commonly used to treat petit-mal (absence) seizures?
  • For detecting pheochromocytoma, which metabolites are primarily measured?
  • Lactate dehydrogenase (LD) measurements are described as what kind of unit related to its subunit composition?
  • Which term describes the process of determining if a patient has a disease?
  • Which micropipettor uses suction to draw liquid into the tip?
  • What is the reference method used for trace element analysis?
  • Which parameter best reflects overall patency of bile flow?
  • Which test is used for monitoring thyroid hormone replacement therapy?
  • Which of the following is not a central tendency measure?
  • What is the reference method for electrolytes?
  • Addison's disease affects sodium and potassium balance due to hypoaldosteronism. Which electrolyte pattern is typical?
  • Which statement best defines pharmacokinetics?
  • ApoB100 main distribution and function?
  • Which condition is listed as a cause of hypernatremia due to increased intake or retention?
  • What is the main endogenous source of cholesterol?
  • Which protein is an example of a tertiary structure?
  • What is the arterialization temperature used in the procedure?
  • What are the two specimens typically used for osmolality determination?
  • Which molecule mediates cell adhesion and is involved in wound healing?
  • In HDL-C measurement using precipitation or immunoassay capture, which component is targeted for removal or binding?
  • Which solutions are used for spectrophotometric calibration methods?
  • How long can samples be stored at -20 C?
  • Which two urinary metabolites are used to assess testosterone activity?
  • Which copper reduction method is most commonly used in glucose measurement?
  • Which condition best corresponds to primary hypergonadism?
  • Lean Six Sigma addresses two questions. Which pair is correct?
  • Which of the following best describes the two items given in the notes?
  • Which of the following is a fully synthetic opiate?
  • Inhibition by wheat germ lectin, which amylase isoenzyme is inhibited?
  • Which hormone initially increases calcium and phosphate release after bone resorption and then excretes phosphate?
  • What is the first and most important screening test for evaluating thyroid function?
  • In electrophoresis scatter, which pattern is associated with small particles?
  • A BUN-to-creatinine ratio less than 10:1 is typically seen in which scenarios?
  • Which statement correctly interprets the range 200-1000 rpm?
  • Which follicle is selected to release the ovum and give rise to the corpus luteum?
  • In galactosemia, which enzyme deficiency is most common?
  • Which set represents the three categories of psychoactive drugs/antidepressants listed?
  • In the copper reduction methods, what is the initial product formed when glucose reduces copper sulfate?
  • What blank is used to correct absorbance due to reagent color?
  • Which markers are associated with hepatic detoxification function?
  • Which plasma protein has the highest affinity for thyroxine (T4)?
  • Which hormone from the anterior pituitary stimulates ovulation and testosterone production?
  • In clinical chemistry, NPN stands for?
  • Which counter type is typically used for beta-emitting isotopes such as H-3 and C-14?
  • What is the preferred duration for sitting or supine lying during phlebotomy?
  • What is the reference method for HbA1c measurement?
  • Macroenzyme 1 is bound to what?
  • What are the reference ranges for AST and ALT?
  • What percent hemolysis corresponds to gross hemolysis?
  • Which indicator is used in the method?
  • Which material is used for sample cells in the visible light region?
  • MODY stands for mature onset of Diabetes of the Young.
  • If fertilization occurs, which hormone helps maintain the corpus luteum?
  • What percentage of testosterone is bound to SHBG?
  • Which electrolyte is described as requiring fasting before measurement?
  • The measuring electrode buffer for a pH electrode is typically which salt solution?
  • The instrument principle used to determine oxygen saturation (O2SAT) in ABG analysis is:
  • Nonfasting lipid analysis is acceptable for two analytes. Which is NOT among them?
  • Normal arterial pH range is:
  • Acid phosphatase (ACP) often has optimal activity at pH approximately:
  • With a 1°C rise, pO2 changes by which percent?
  • The Martin-Hopkins method estimates VLDL using which approach?
  • What is unique about scintillation counting compared with other luminescence methods?
  • In the Biuret assay for proteins, how many peptide bonds are required for a positive reaction?
  • The Zimmerman test for 17-ketosteroids uses which reagent, and what color indicates a positive result?
  • Which metric equals TN divided by (TN plus FP)?
  • Which enzyme is NOT listed among the nine enzymes with macroforms?
  • Which pair of reagents corresponds to the two calcium precipitation techniques?
  • What is the critical pO2 value threshold?
  • What is the product of inner deiodination of T4?
  • In nutritional status assessment, which sequence correctly orders the markers from highest to lowest as listed?
  • In LDL homogeneous assay, which component is measured enzymatically after separation?
  • Calibration of the pCO2 electrode requires which standard?
  • Which luminescence technique uses ruthenium tris chelate as a substrate?
  • Spectrophotometry measures what type of light?
  • What is the correct expression for the anion gap as described in the material?
  • Which estrogen is described as cardioprotective and involved in coagulation?
  • Which detection methods are used for glucose oxidase–based measurements?
  • Which factor inhibits growth hormone secretion?
  • What are the three steps in the 3-step precipitation method?
  • Cocaine is described as a potent cardiac toxin that can cross the placenta and breast milk.
  • Impairment of which hormone/neurotransmitter is linked to higher drug dependency?
  • What is the reference range for Free Thyroxine Index (FTI)?
  • In the Lean 5S framework, what is the fourth S?
  • In Beer's Law, if the concentration doubles and the absorptivity and path length remain constant, what happens to absorbance?
  • In a Water Loading Test with 20 mL/kg ingestion, what is the normal urine response?
  • In glucose oxidase-based enzymatic assays, hydrogen peroxide participates in the detection step by reacting with a chromogen to produce color. Which statement best describes this role?
  • Which components define acid-base balance among the listed electrolytes?
  • Nesslerization in ammonia measurement yields which color?
  • Which transporter pumps free cholesterol to lipid-poor HDL to form nascent pre-B HDL?
  • What is the critical range for potassium?
  • What is the detection limit of a luminometer?
  • In the ferric reduction method, what color is the product formed after reaction with glucose?
  • Which condition causes a rightward shift of the simplified oxyhemoglobin dissociation curve?
  • Marker for bone resorption
  • Which of the following is NOT an example of a protein hormone?
  • What is the most common clinical use of tumor markers in cancer management?
  • Which of the following is a glycopeptide hormone?
  • Which unit would you expect to see for cytocentrifuge speed in a protocol?
  • Which medication is listed as a cause of normal anion gap metabolic acidosis (HARDASS)?
  • Which are the forms of subacute thyroiditis?
  • The dilution factor D is defined as
  • According to the SIBICO mnemonic, which statement is true?
  • For most drugs in therapeutic drug monitoring, what is the preferred specimen?
  • Drug metabolism occurs primarily in which organ?
  • What is the normal albumin-to-creatinine ratio in mg/g?
  • Which pairing correctly matches a testosterone disorder with its typical cause?
  • Which ALP isoenzyme is most heat stable and associated with lung cancer?
  • During IV sampling, how long should the IV be turned off and how much first sample should be discarded?
  • Which ABG handling practice is recommended?
  • Which of the following is a common support medium for electrophoresis?
  • Which marker is used postoperatively to monitor thyroid cancer?
  • What is a urinary metabolite of progesterone?
  • Which complication is primarily associated with type 1 diabetes?
  • What are the two forms of chromatography?
  • Estimated total body water for a 70 kg male is approximately how many liters?
  • Which CK isoenzymes are described as heat sensitive at 60°C?
  • Stray light is tested using which instrument component?
  • In drug transport, which protein predominantly binds drugs under acidic conditions?
  • Air exposure of a specimen tends to cause which combined change?
  • How long should plasma and cells be separated after collection to minimize glycolysis effects?
  • Under alkaline conditions, which is the primary drug transport protein?
  • Which pair correctly describes the two common methods for measuring bicarbonate in clinical chemistry?
  • Placenta: which effect regarding insulin?
  • How many types of thermometers are listed?
  • Which statistic is used to confirm accuracy?
  • What is the normal reference range for total protein in serum?
  • Which apolipoprotein has main distribution in chylomicrons, VLDL, and HDL and functions as a structural component?
  • What is the blood to plasma ratio for therapeutic drug monitoring monitoring?
  • Which markers are used to monitor for recurrence after breast cancer treatment?
  • Which reagent is used to stain CSF for protein analysis in electrophoresis?
  • Which hypothalamic releasing hormone stimulates the release of ACTH from the anterior pituitary?
  • Which apolipoprotein is predominantly distributed in HDL and has a structural role?
  • In the ALT assay using pyruvate, what is the reaction product?
  • Direct spectrophotometry of total bilirubin is measured at which wavelength?
  • Which cleaning method is listed as best for plastic and glassware?
  • Which lipoprotein density range corresponds to LDL?
  • What is the normal range for 1,5-anhydroglucitol (1,5-AG)?
  • Which condition yields the highest elevation of alkaline phosphatase (ALP)?
  • In the Biuret reagent, which base is used?
  • Which two hormones are produced by the adrenal medulla?
  • Moderate elevation of LD corresponds to which ULN range?
  • Antiglycolytic agents prevent the decrease of which metabolite?
  • Major substrate precursor of adrenal cortex hormones?
  • Hyponatremia due to vomiting and diarrhea is due to which mechanism?
  • Which of the following are cofactors in enzyme reactions?
  • For TCO2 measurement, which method alkalinizes all CO2 to bicarbonate for measurement?
  • If TAG is high, LDL-C is determined using which method?
  • Beta-gamma bridging due to IgA is associated with which condition according to the material?
  • Which parameter represents constant systematic error?
  • In the perfect correlation principle, what is the Y-intercept?
  • Which marker is used as an obesity marker in the material provided?
  • What is the critical range for pCO2 in arterial blood gas values?
  • From most anodal to least, what is the order of amylase isoenzyme mobility?
  • In gravimetric calibration, what solution and condition provide the most accurate standard?
  • What fraction of extracellular fluid is intravascular (plasma)?
  • Which type corresponds to Familial Dysbetalipoproteinemia?
  • Which statement correctly describes the structural difference between T3 and reverse T3?
  • Which liver macrophages are part of the reticuloendothelial system?
  • Which method is described as cheap but insensitive for urea determination?
  • What is the typical turnaround time for routine laboratory testing?
  • What is the reference range for albumin in serum?
  • The parameter associated with the cytocentrifuge in the notes is measured in which unit?
  • Which mediator is produced by the liver and mediates the action of growth hormone?
  • Thiamine deficiency can cause which conditions?
  • Anodic stripping voltammetry is used to detect which metals?
  • In brain tissue, which marker is more abundant: CKBB or Aldolase C?
  • Wetting agents or incorrect pH have what effect on unconjugated bilirubin?
  • Which hormone is part of the FLAT acronym for anterior pituitary tropic hormones?
  • In a Cusum chart, which axis represents the run number?
  • What centrifugation speed range and time are standard for separating serum?
  • What is the process of testing and adjusting an analyzer's readout for correlation with a standard called?
  • In ultracentrifugation, which lipoprotein resides in the topmost layer?
  • What is the commonly accepted reference range for blood urea nitrogen (BUN) in mg/dL?
  • Which lipoprotein is described as floating prebetalipoprotein with high cholesterol content?
  • Which of the following is a B1 hepatic disease?
  • The Szasz assay for GGT uses which substrates?
  • Which statement correctly contrasts polyclonal and monoclonal gammopathy?
  • Aspirin overdose commonly causes which acid-base disturbance?
  • Which MS technique is used for proteomics and microbial ID?
  • Which trace element is essential for DNA and RNA synthesis as a key cofactor?
  • Wavelength accuracy in spectrophotometry is assessed using which materials?
  • Which medium is used for size-based separation in electrophoresis?
  • An advantage of carbonic acid as the main buffer is that it can provide H+ and HCO3- for buffering.
  • Calibration should be performed every 6-12 months.
  • How often should semi-automated micropipettors be calibrated?
  • Decreased albumin with increased a1 and a2 is most associated with which condition according to the material?
  • Antiglycolytic agents are used if three tests are done in more than how many hours?
  • What term describes the integration of chemistry and immunoassay in modern analyzers?
  • Which tumor increases both AFP and hCG?
  • Which statement best aligns with the material regarding insulin?
  • In males, LH stimulates which cells to produce which hormone?
  • Which tube type is used to obtain serum after clotting?
  • Which tests are used to evaluate subclinical or subacute hyper- or hypothyroidism?
  • FT3 is normally tested only when which two test results are observed?
  • What is the most common cause of hypophosphatemia?
  • Prolonged bedrest decreases which serum protein?
  • Which Fredrickson Type is Familial combined hyperlipoproteinemia (high LDL and VLDL)?
  • Which of the following is a cellulose derivative used as a support medium in electrophoresis?
  • Sitting to supine posture leads to what change in plasma concentration?
  • Which enzyme is used in the enzymatic ammonia assay?
  • In Friedewald estimation, VLDL in mg/dL is calculated as TAG divided by what factor?
  • ADA HbA1c target for many adults with diabetes is less than what percent?
  • Which of the following is NOT listed as a regulator of body water balance?
  • What is the absorbance maximum for the Jendrassik Groff method?
  • Which are two components of continuous flow systems?
  • Na+/K+-ATPase pump uses what type of transport?
  • Water for higher purity techniques is designated as Special reagent water.
  • Slight elevation of LD corresponds to which ULN range?
  • Which analyte increases when serum or plasma is stored at 4°C?
  • The photomultiplier tube (PMT) amplifies light by approximately how many times?
  • Which equation correctly represents the Michaelis-Menten model for velocity v as a function of substrate concentration [S]?
  • Which enzyme esterifies free cholesterol inside nascent pre-B HDL to form mature alpha-HDL?
  • Is 800 rpm within the specified cytocentrifuge speed range?
  • Which element has an atomic weight of about 23?
  • Which of the following is an aldose?
  • Which plastic is autoclavable primarily for temperature tolerance?
  • Which condition is NOT associated with increased AFP?
  • Glucose binds to which site on hemoglobin?
  • Which combination of anterior pituitary hormones is released in response to Thyrotropin-Releasing Hormone?
  • Which drugs contribute to hyperkalemia by inhibiting uptake by the heart via Na+/K+ ATPase?
  • Which statement correctly describes steroid hormones?
  • Which trace element tends to bind sulfhydryl groups in proteins?
  • Which LD isoenzyme remains active after heat denaturation?
  • During pregnancy, after the first trimester, which structure is the major producer of progesterone?
  • What is the alkaline reagent provided in the Reitman Frankel reaction?
  • What color is produced in the Evelyn-Malloy color reaction?
  • Phototherapy for neonatal jaundice decreases bilirubin by what percentage per hour?
  • Which statement correctly describes Metyrapone?
  • For photosensitive materials, which glass type is used?
  • What is the heparin concentration in ABG collection per milliliter of blood?
  • In kidney disease, BUN is high in blood and high in urine; in liver disease, BUN is low in blood with a BUN ratio less than 10:1.
  • For osmolality determination, which specimen is listed in the material?
  • In laboratory terminology, a method with documented accuracy and precision is referred to as what?
  • Which molecules form the ammonium-selective membrane in ion-selective electrodes?
  • Which LD measurement method is more common?
  • Which of the following are secondary markers for obstructive jaundice?
  • Hypoxanthine Guanine Phosphoribosyl Transferase is associated with the conversion of uric acid to which compound?
  • The limit of detection for CLIA is expressed as zeptomoles, equal to which exponent?
  • In the placenta's trimester-specific production, which hormone is primarily produced during the second trimester?
  • A BUN-to-creatinine ratio greater than 20:1 with a normal creatinine level is most consistent with which condition?
  • Prerenal azotemia is suggested by which pattern of BUN and creatinine?
  • Which equation is more commonly used to estimate glomerular filtration rate than Cockcroft-Gault and MDRD?
  • In skeletal muscle, which marker is most abundant according to the given abundance order CK1 > AST > Aldolase > LD4,5?
  • In glucose measurement using glucose dehydrogenase, which cofactor is detected?
  • Altitude in feet at which blood volume decreases when collected?
  • In the standing plasma test, what indicates the presence of both VLDL and chylomicrons?
  • Which method is used as a reference method for HbA1c analysis in clinical labs?
  • Which sugar is non-reducing?
  • What structure connects the hypothalamus to the anterior pituitary?
  • Hyperglycemic hyperosmolar nonketotic coma is most commonly associated with which type of diabetes?
  • Ammonia constitutes what percent of total non-protein nitrogen (NPN)?
  • Which method is colorimetric-spectrophotometric for transaminase determination?
  • What is the conventional unit for enzyme activity expressed as μmol per minute?
  • Which factor is listed as causing a rightward shift of the oxyhemoglobin curve by increasing metabolic activity?
  • VLDL is faster than LDL in electrophoresis because VLDL is more negatively charged. True or false?
  • Another consequence of squeezing the puncture site is the introduction of what into the specimen?
  • Which of the following is NOT listed as a common interference in Trinder-type glucose assays?
  • What is the stated lethal daily dose of lead?
  • Which blood collection tube is sensitive to sunlight and should be protected from light for proper coagulation testing?
  • Spectroscopy is categorized into two main groups. Which list correctly pairs examples for emission and absorption methods?
  • Which formula defines Positive Predictive Value?
  • Which sequence correctly lists the three stages of alcoholic liver disease?
  • Von Gierke disease (Type I glycogen storage disease) is due to deficiency of which enzyme?
  • Which condition shows TSH normal, FT4 normal, TT3/TT4 high, and T3 uptake low due to high thyroid-binding globulin?
  • Which type of silica glassware is considered best among three silica glassware options?
  • Which of the following is NOT a Dye Lake dye?
  • In arterial blood gas sample handling, pH decreases by how much for every 20-minute delay?
  • Which dye is most commonly used as a calcium-binding dye in spectrophotometric assays?
  • Which test differentiates neurogenic DI from primary polydipsia?
  • Which hormone from the anterior pituitary triggers ovulation?
  • Which enzyme is common to both enzymatic triglyceride measurement methods?
  • In acidemia (acidosis), what happens to ionized calcium?
  • Tacrolimus is approximately how many times more potent than cyclosporine?
  • Km is defined as substrate concentration at what fraction of Vmax?
  • Which enzyme acts as a hydrolase and is used as a marker for liver disease?
  • What happens to pCO2 and pH when air bubbles are present in the sample?
  • Pronounced elevation of LD is defined as which multiple of the ULN?
  • Which of the following is NOT listed as a cause of hypomagnesemia?
  • What is the recommended cuff pressure to use as a tourniquet during venipuncture?
  • T3 Uptake provides what kind of relationship to thyroxine-binding globulin (TBG)?
  • Which form is the active form of vitamin D?
  • Acid cleaning solutions contain which compound in concentrated sulfuric acid?
  • Which amino acids contribute to protein absorbance at 280 nm?
  • Which component of the simplified quality scheme is described as monitoring only precision?
  • The two toxic effects associated with Aminoglycosides and Vancomycin are:
  • Which lipoprotein is characterized by cholesterol being greater than protein as its major component?
  • What is the colored reaction product formed in the Reitman Frankel method (denoted as brown)?
  • Which MS technique is typically used for drug analysis?
  • What type of feedback regulates oxytocin release during labor?
  • What are the two most common chromogens used in Trinder-type glucose assays?
  • Which metal is associated with two diseases named Pink disease and Minamata disease?
  • What is the recommended butterfly needle length?
  • Which enzyme has the highest circulating concentration?
  • Glycerol + periodic acid yields which product?
  • What is the electrophoretic order from cathode to anode?
  • Tartrate inhibits which ACP source?
  • Which of the following describes Type 2 reagent water characteristics?
  • Which enzyme's decrease is clinically significant?
  • Calibration of the pH electrode requires which of the following?
  • Which hypothalamic releasing hormone stimulates the release of FSH and LH?
  • What is the recommended fasting duration before a 2-hour OGTT?
  • Which test increases specifically in ESS/NTI?
  • Which plastic is autoclavable due to chemical and temperature resistance?
  • Which Aldolase isoenzyme is primarily located in brain tissue?
  • Quaternary structure is stabilized by which interactions?
  • In the Reinsch test, which color indicates mercury?
  • Which drugs are considered first-generation antiepileptics that require therapeutic drug monitoring?
  • Which two parameters are calibrated in centrifuge performance, and how frequently should calibration be performed?
  • Which of the following is NOT a continuum light source?
  • By what factor does BUN convert to urea?
  • Extra bands in plasma and hemolyzed serum during electrophoresis and their locations?
  • Which non-protein nitrogen does not measure kidney function?
  • What are the intermediate products before urea is produced?
  • In renal dysfunction, which statement best describes urine amylase and urine creatinine levels?
  • By how many fold is 24-hour urine free cortisol typically increased in primary hypercortisolism?
  • In the simplified quality scheme, QA is applied to how many analytic areas?
  • Which instrument is used to measure divalent ions and trace elements via photometric methods?
  • In the Cockcroft-Gault equation, which factor is applied if the patient is female?
  • The RST clotting time is limited to how many minutes?
  • After precipitation or color method, which chelating agent is commonly used to separate calcium from dyes and reach endpoint color?
  • Diagnostic tests of hypoglycemia?
  • Glucose decreases per hour under room temperature conditions?
  • For transaminase elevations, acute hepatitis and liver necrosis reach what multiple of ULN?
  • How should a cortisol sample be collected for accurate measurement?
  • Which method is used to separate and quantify catecholamine metabolites such as HVA and VMA in urine?
  • Busulfan belongs to which class of chemotherapeutic agents?
  • Which statistical test is used to compare the means of two groups?
  • Which form of mercury is primarily considered an environmental pollutant?
  • Which anticoagulant is preferred for ABG analysis?
  • What is the major CK isoenzyme in skeletal muscle, constituting about 94-100%?
  • Which stopping agent is used in the Jendrassik Groff method?
  • Initial control limits are established by analyzing controls over how many consecutive days?
  • Which tumor increases hCG only?
  • Which statistical test is used to assess precision (variance)?
  • Which conjugated protein type has the highest carbohydrate content?
  • In air-displacement micropipettors, the tip is made of which material?
  • In the simplified quality scheme, CQI primarily focuses on which activity?
  • Threshold limit value is the allowable exposure for an employee during an __ hour day.
  • In the pathway, which sequence best describes the conversion: DHEA to testosterone to estrogen?
  • The Ferro-Ham chloranilic acid precipitation method for calcium uses which acid as reagent?
  • Deficiency of which vitamin leads to hemorrhage and bruising?
  • In flame photometry, which color corresponds to barium emission?
  • Which enzyme catalyzes the initial carboxylation of phosphoenolpyruvate with bicarbonate to form oxaloacetate in the described pathway?
  • Which dispersive element yields non-linear dispersion and is used for higher frequency light?
  • Among the diurnal variation list, which hormone is higher in the PM period?
  • Which of the following is a reason discrete analyzers are named as such?
  • Steady state is typically achieved after how many half-lives?
  • What is the arterial puncture angle for the femoral site?
  • Which two analytes increase when serum is stored at room temperature?
  • Which enzymatic creatinine method uses creatininase with peroxidase (POD) as part of the coupled reaction?
  • What is the major cause of an outlier in assay results?
  • Which dye-binding reagent is most common for albumin measurement?
  • In gross hemolysis, which enzyme activity is most affected?
  • Routine renal function testing commonly measures which biomarker?
  • In malnutrition indicators, transthyretin is used as a marker for which condition?
  • What is considered a desirable VLDL level?
  • Liquid excess anticoagulant effect leads to which change?
  • Hyperkalemia due to cellular shift is most strongly associated with which condition?
  • Which of the following is a DOWNTIME waste?
  • THBR stands for which term?
  • Fanconi-Bickel syndrome is associated with a defect in which transporter?
  • Which enzyme converts T4 to T3?
  • Which substance is a classic unmeasured anion contributing to high anion gap metabolic acidosis?
  • For every 100 mg/dL increase in glucose, how many mmol/L of sodium decrease?
  • In the MDRD equation, how many variables are used?
  • Type 2 diabetes mellitus is non-insulin dependent diabetes mellitus (NIDDM).
  • Abrupt loss of albumin is most commonly associated with which condition?
  • Euthyroid with low TBG occurs in which situations?
  • The Ferriman-Gallwey Scale is used to grade which clinical feature?
  • Which enzyme is described as the smallest enzyme in this context?
  • Which class of hormones is characterized by water-soluble solubility, no carrier, and a half-life of about 10-30 minutes?
  • What is the reference range for ammonia in micrograms per deciliter?
  • Which urinary metabolite is the end product of metabolism for both epinephrine and norepinephrine?
  • Lead exposure inhibits enzymes involved in which essential process?
  • In euthyroid sick syndrome, which hormone is elevated?
  • What color is produced in the Jendrassik Groff color reaction?
  • In the AST assay employing MDH, what is the reaction product?
  • Which set of changes is characteristic of uremia?
  • Which lipoprotein is the most atherogenic lipid and the primary marker of coronary heart disease?
  • Glycogen stores are depleted within approximately how long during fasting?
  • Which adrenal medulla tumor is typically associated with increased VMA but not HVA?
  • Which value represents a Normal triglyceride level?
  • Fructosamine is indicated in which conditions?
  • What is the upper limit of the normal osmolal gap (mOsm/kg)?
  • Which adipokine is inversely associated with metabolic syndrome risk?
  • In the Free Thyroxine Index formula, T3U is divided by what value?
  • What is the rapid screening method for trace elements?
  • Which enzyme is inhibited by antiglycolytic agents?
  • Which laboratory method is used to detect urinary estrogen via a color reaction and yields pink on a positive result?
  • Pituitary adenoma size is defined as microadenoma or macroadenoma. A microadenoma is defined as less than how many centimeters?
  • Which of the following is a ketose?
  • What is the reference range for total protein in serum?
  • Prealbumin serves as a transport protein for which hormone or molecule?
  • Creatinine and BUN are not increased until GFR decreases by about what percentage?
  • Which trace element is classically associated with a garlic odor in poisoning cases?
  • Triose phosphate isomerase is categorized under which enzyme class?
  • Kinase enzymes belong to which category?
  • Which of the following is NOT a sedative/hypnotic/CNS depressant listed?
  • Which substance increases in the blood as a result of cigarette smoke exposure?
  • Which hormone from the anterior pituitary stimulates the production of thyroid hormones?
  • A BUN-to-creatinine ratio greater than 20:1 with an elevated creatinine level is most consistent with which type of azotemia?
  • Which test is described as the most specific and sensitive test for thyroid dysfunction?
  • Which minerals are involved in production and use of ATP from glucose?
  • In chemical storage, acids should be stored separately from bases.
  • For every degree Celsius increase, the reaction rate approximately doubles? (temperature rule)
  • In the Kober test for urinary estrogen, which reagent yields a pink color with sulfuric acid?
  • Which material is used as the chloride-selective membrane in ion-selective electrodes?
  • Which protein is NOT a beta-globulin?
  • Which statement about systematic errors is true?
  • What fraction of total body water is intracellular?
  • Which method is considered the reference method for total protein measurement by nitrogen content?
  • Which vitamin is known to interfere with some immunoassays when taken in excess?
  • What is the ferritin reference range for healthy adult men?
  • The measuring electrode buffer for a pCO2 electrode is usually which buffer?
  • Which light source covers the spectrum from ultraviolet to visible?
  • Which hormone reflects placental function and remains increased throughout pregnancy, aiding estrogen and progesterone production?
  • In the Berthelot method for ammonia determination, which color is produced that is detected colorimetrically?
  • Which of the following is a classic cause of increased anion gap metabolic acidosis?
  • Gc-Globulin is also known as which protein?
  • In the 3 diazo reagents setup, what is Diazo A composition?
  • Which of the following describes polyacrylamide-based gel electrophoresis?
  • Which expression correctly calculates osmolality from measured sodium, glucose, and BUN?
  • Gestational diabetes mellitus may convert to type 2 diabetes in 30–40% of cases within 10 years.
  • The isoelectric point is the pH at which a protein has a net charge of what?
  • Six Sigma is applied primarily to achieve what?
  • What are the two general methods for triglyceride measurement?
  • Postprandial glucose normalizes after how many hours following a meal?
  • 1 mole D-Glucose equals how many osmoles when dissolved in water?
  • According to NCEP goals, if CHD is present, the LDL-C target is:
  • Gross hemolysis can falsely elevate CK measurements due to the release of which enzyme?
  • The venous anion gap typically falls within which range?
  • Macro-CK or IgG-bound CK1 is associated with an apparent increase in which CK isoenzyme?
  • What is the rpm for a horizontal head (swinging-bucket) centrifuge?
  • In automation, what does discrete mean?
  • What term describes the amount of solute in a given amount of solution?
  • Which triglyceride level category indicates high risk for CHD?
  • First abnormality and recovery seen in hyperthyroidism is which index?
  • In a double-beam spectrophotometer, how many detectors are used and how many beam splitters are there?
  • pH of maximum activity for most enzymes is typically around:
  • Which of the following is a measuring pipet?
  • Which method characterizes third-generation TSH assays?
  • If you list both cytocentrifuge speed and osmolality specimen in a single statement, which would be correct?
  • Which acids are graded as 2 in the laboratory severity scale?
  • What are the two major sources of ACP?
  • What is the length range given for microwaves?
  • In the enzymatic determination of urea, what is produced when urea reacts with urease?
  • What is the expected result of an overnight dexamethasone suppression test in primary hypercortisolism?
  • The F-test ratio is defined as the ratio of which quantities?
  • Which technique is more sensitive than fluorometry?
  • In tetany due to hypocalcemia, the calcium level is typically which of the following?
  • Which enzymes are typically elevated in a space-occupying lesion in the liver?
  • What is the critical range for magnesium?
  • Markers for preterm delivery and threatened abortion
  • The highest CK elevation is observed in which condition?
  • In congenital adrenal hyperplasia due to 17α-hydroxylase deficiency, which metabolite is reported as high?
  • The F-test is considered significant if the ratio exceeds which threshold?
  • A negative difference is described as which directional shift?
  • Continuous Monitoring/Kinetic assays are defined by which feature?
  • Which condition is listed as a cause of a low osmolal gap?
  • The T-test formula used here uses which numerator?
  • In rapid screening methods for trace elements, the sample used is urine.
  • Which marker measures very short glycemic control over about 1-2 weeks?
  • What bilirubin level constitutes a panic value for kernicterus?
  • Sertoli cells produce which two substances?
  • In primary hypothyroidism, which pattern best matches TSH, FT4, TT3/TT4, and T3 uptake?
  • Main source of error in lipase determination?
  • Approximately how many grams does 1 milliliter of pure water weigh?
  • The post-postanalytical phase covers which activity?
  • Which molecule is an organic coenzyme?
  • In the simplified quality scheme, which term represents the overall program ensuring results meet healthcare service requirements?
  • What percentage of total NPN is urea?
  • Mercury exists in three forms. Which option correctly lists these forms?
  • Main source of error in amylase determination?
  • Potassium levels in ectopic Cushing syndrome are typically:
  • Calcitonin is most closely associated with which thyroid disease?
  • Which pair of serum proteins are negative acute-phase reactants?
  • What is the normal osmolal gap range?
  • An increased beta or an unusual band between alpha-2 and beta indicates which condition?
  • Which of the following is a Dye Lake dye?
  • Lactate produced in anaerobic glycolysis yields how many ATP per glucose?
  • The conductimetric method for ammonia detection relies on which observable change?
  • What is considered the best specimen for arterial blood gas (ABG) analysis?
  • Standard QC uses how many levels and how often?
  • Direct osmolality is measured by which instrument?
  • Which photodetector is noted for excellent linearity?
  • Which chart can only detect systematic error?
  • Which statement best describes the diagnostic criterion for insulinoma/endogenous hyperinsulinism after fasting?
  • Which technique is used as a reference method for HbA1c measurement?
  • In the 3 diazo reagents setup, what is Diazo B composition?
  • Which additive is used in coagulation testing tubes?
  • Which technique is an amperometric method?
  • Which reagent is used to differentiate LD isoenzymes on gels?
  • Which of the following is listed as a hyponatremia cause under 'Other causes'?
  • Which criterion is used to stage acute kidney injury?
  • Not prone to false negatives is best described as which analytical property?
  • In uremia, which electrolyte and acid-base disturbances are commonly observed?
  • Which equation correctly represents the Henderson–Hasselbalch expression for pH in terms of bicarbonate and carbonic acid?
  • In immunoassays for therapeutic drug monitoring, which description matches Microparticle Enzyme Immunoassay?
  • Which support is used in thin-layer chromatography (TLC)?
  • McArdle disease is caused by deficiency of which enzyme?
  • Which molecule is formed when glucose is phosphorylated in the first step of glycolysis?
  • In acute pancreatitis, amylase typically peaks at approximately how many hours after onset?
  • What is the reference range commonly cited for alkaline phosphatase activity in U/L?
  • Which of the following lists the four colligative-property changes associated with high osmolality?
  • Before a 2-hour OGTT, carbohydrate intake should be at least what amount for 3 days?
  • Glutathione synthetase belongs to which enzyme class?
  • For viscous samples, which pipetting mode is recommended?
  • Which two proteins are referred to as enzymatic carriers?
  • Kasahara isoenzyme is associated with which cancer?
  • In hemolytic anemia (HA), how are G6PD and PK levels affected?
  • What density and duration are used in ultracentrifugation for HDL-C isolation?
  • How are air bubbles prevented during sample collection?
  • In the refrigerator test pattern, which observation corresponds to No CLOT and Clear Plasma with Increased B band (Pattern 2a)?
  • Which electrolyte primarily regulates the ATPase ion pumps?
  • Electrophoretic mobility: which lipoprotein shows pre-beta mobility?
  • Which of the following is a recognized class of enzymes?
  • Which item is NOT listed as an analytical element in RECSQ?
  • Which of the following is NOT a proliferation signal inhibitor?
  • Which enzyme in the enzymatic cholesterol method is responsible for producing hydrogen peroxide in the reaction sequence?
  • Which specimens are commonly used for measuring HVA/VMA by HPLC?
  • What is the product formed in the phosphate determination using the Fiske Subbarow method?
  • Linearity of the instrument is checked using which materials?
  • What is the major cause of a trend in assay results?
  • In the chemical method using alcoholic KOH, what are the products?
  • Which statement is supported by the notes regarding osmolality testing?
  • Transferrin formula
  • What is the standard tool used to assess random error in determination?
  • Which term describes the ability of a substance to dissociate in water?
  • Which is the most potent male androgen?
  • What is the most common anterior pituitary gland tumor?
  • Which electrolytes are involved in blood coagulation?
  • Which Fredrickson Type corresponds to Familial chylomicronemia (LPL deficiency)?
  • Which urinary metabolite of cortisol is detected using the Porter-Silber Method with 2,4-DNPH and yields a positive yellow reaction?
  • Which instrument is used for excitation by electromagnetic radiation?
  • In the chemical method, which step uses Bloom's reagent for extraction?
  • What is the typical angle used to detect scattered light in nephelometry?
  • What are the phases of subacute thyroiditis in order?
  • Hers disease is due to deficiency of which enzyme?
  • Which compound is the most abundant non-protein nitrogen (NPN) substance?
  • Mercury exposure is classically associated with Pink disease.
  • In a standard curve used for quantitative analysis, what is plotted on the X axis and Y axis?
  • For whole blood, which approach can be used with slight modifications (pre-wetting first)?
  • Which of the following is also an indication for arterial puncture?
  • Mercury exposure routes include which of the following?
  • A positive difference corresponds to which directional shift?
  • In freezing point osmometers, the sample is typically cooled to approximately what temperature?
  • Which lipase assay uses colorimetric detection with glycerol kinase and peroxidase?
  • The half-life of delta bilirubin is approximately how long?
  • Which condition shows decreased radioactive iodine uptake (RAIU) compared with other hyperthyroid conditions?
  • Which pair of agents is associated with hypokalemia due to intracellular potassium shift by increasing Na+/K+ ATPase activity?
  • Which technique is typically categorized as potentiometry?
  • What is the maximum coefficient of variation allowed for LDL-C measurements under NCEP guidelines?
  • For metanephrine testing to screen pheochromocytoma, which result is preferred?
  • In the diaphorase method for enzymatic glucose measurement, the colorimetric product is which color?
  • Which CK isoenzyme is the mitochondrial form?
  • HDL precipitation requires triglyceride levels to be below what value for efficiency?
  • What is the primary action of atrial natriuretic peptide on sodium?
  • In indirect calculation of LDL-C, which set of values is required?
  • What is the reference method for measuring non-protein nitrogen (NPN) in clinical chemistry?
  • What is the defining feature of polyclonal gammopathy on electrophoresis?
  • Which is the most abundant prehormone of T3?
  • Which method for glucose measurement uses hexokinase?
  • CK-BB is elevated in which condition according to the material?
  • Which ABG analytes are directly measured?
  • What is the absorbance maximum for the Evelyn-Malloy method?
  • Osmolarity is expressed in which units?
  • Which specimen uses EDTA among the listed items?
  • Hyponatremia due to increased water retention is commonly associated with which condition?
  • What is the FT3 reference range for females?
  • What is the method used for sweat chloride testing?
  • The CDC method for HDL-C includes three processes: Ultracentrifugation, precipitation by heparin-manganese, and which method?
  • The syringe plunger contains trace elements due to the material; which elements are present?
  • According to the rule of normality and molarity, which relation holds?
  • Elevated gamma-glutamyl transferase (GGT) is most associated with diseases of which organ?
  • Which option is outside the cytocentrifuge speed range of 200-1000 rpm?
  • Which analytical technique involves fragmentation and ionization of molecules for analysis?
  • TBPA stands for which of the following in the context of thyroxine transport?
  • Triglycerides require fasting for how long to ensure accurate measurement?
  • Equivalent weight is calculated as
  • Primary bile acids are which?
  • Which Aldolase isoenzyme is predominantly found in skeletal muscle?
  • What is the rule of CV acceptability in method validation?
  • Pink disease is associated with exposure to which metal?
  • Kernicterus risk is associated with bilirubin levels exceeding what value?
  • Subclinical hypothyroidism is best described by which pattern of TSH and FT4/TT3/TT4?
  • Bronze diabetes is associated with which condition?
  • Which protein is also known as orosomucoid?
  • Which method is the reference method for ethanol measurement?
  • Normal arterial pO2 range is:
  • Which paracrine regulator of insulin and glucagon is produced by delta cells of the pancreas?
  • In the Porter-Silber test for hydroxycorticosteroids, what color is produced when DNPH is used?
  • In insulinoma, the expected lab pattern is insulin high, proinsulin high, C-peptide high, and B-hydroxybutyric acid low.
  • In the colorimetric chemical method, the S reagent produces what color product?
  • After obtaining the T3U value, what is the next test that can be performed?
  • In cholesterol transformation, which form is considered transformable cholesterol?
  • In the high-dose dexamethasone suppression test, which pattern best distinguishes Cushing's disease from ectopic ACTH production?
  • Which test detects early renal complications in diabetes?
  • Which statement correctly defines Negative Predictive Value?
  • Pseudohyponatremia is a laboratory artifact related to which measurement method?
  • Which plastic is used for cryogenic purposes such as pipet tips and test tubes?
  • Night blindness is associated with deficiency of which vitamin?
  • Which biomarker list is associated with Alzheimer's disease?
  • 1 mole NaCl equals how many osmoles when dissolved in water?
  • Compared to a weak acid, a strong acid has what pKa value?
  • For compliant diabetes patients, HbA1c should be tested how often?
  • Which methods are used to measure sodium in the laboratory?
  • Which enzyme pattern is associated with hepatobiliary (cholestatic) injury?
  • Elevated 11-deoxycorticosterone (11-DOC) is characteristic of deficiency of which enzyme in congenital adrenal hyperplasia?
  • Which of the following trisomies is NOT among those associated with decreased AFP?
  • In acute diarrhea, sodium is typically:
  • Which group of risk factors promotes atherosclerosis?
  • Which protein transports retinol (Vitamin A) in the blood?
  • Which hypothalamic releasing hormone stimulates growth hormone release from the anterior pituitary?
  • Under CLIA, non-waived quantitative tests require how many control levels per day?
  • Which biomarker is not an enzyme but rises earlier than CK-MB in AMI?
  • Which buffer is used for acidic conditions in electrophoresis?
  • In a standard diagnostic 2x2 table, the Positive and Negative rows refer to which concept?
  • Which is the reference method for amylase determination?
  • What type of centrifuge head is used for microhematocrit tubes?
  • In fluorometry, what is the typical angle between the excitation and emission monochromators?
  • Which components are used to calculate calculated osmolality?
  • Which metric is defined as the probability that a positive test result is actually a true positive?
  • Which protein has the highest concentration in the alpha-1 band during electrophoresis?
  • Which LDL-C determination method is a direct homogeneous assay that uses detergents?
  • Which glassware is known for high thermal resistance due to its borosilicate composition?
  • What are the two lights described in fluorometers?
  • What term describes the total range of wavelengths transmitted between two points?
  • Electrophoresis is affected by which factors?
  • CFU/mL stands for what?
  • Which analyte is commonly protected from light during storage or handling?
  • Which lipoprotein is prothrombotic and homologous to plasminogen due to its Apo B-100?
  • What is used as the screening test for growth hormone excess?
  • Which LD isoenzyme is cold-labile?
  • Which biomarker serves as an early predictor of acute kidney injury?
  • What is a key difference between molality and molarity?
  • Each 1% increase in HbA1c corresponds to an approximate rise in plasma glucose of how many mg/dL?
  • In primary hyperaldosteronism, a plasma aldosterone to plasma renin ratio diagnostic threshold is greater than what value?
  • Which type of glass is the most inexpensive?
  • Which signaling mechanism involves the hormone remaining bound to the adjacent target cell?
  • Among lipoproteins, which has the highest cholesterol content?
  • Indirect estimation of the free T4 in the blood is known as which index?
  • Which protein remains negatively charged even in acidic pH?
  • Which two anterior pituitary hormones act as insulin antagonists?
  • What is the NCEP target for total cholesterol (TC) in mg/dL?
  • Which of the following is NOT listed as ionizing radiation?
  • Nonfasting lipid analysis is acceptable for two analytes. Which pair are these two?
  • Pompe disease is caused by deficiency of which enzyme?
  • Which hormone is primarily responsible for promoting glycolysis, cellular uptake, glycogenesis, and lipogenesis?
  • Normal arterial pCO2 range is:
  • Hashimoto's thyroiditis is associated with antibodies including anti-thyroglobulin, anti-TPO, and anti-microsomal antibodies. Which option lists these antibodies?
  • Panic values for bicarbonate (HCO3) are at which levels?
  • What is the most common cause of thyroid disease?
  • What is commonly used as the basis to identify a solute in GC/HPLC?
  • In the Oliver-Rosalki CK determination method, which reaction uses hexokinase and G6PD along with CK?
  • Which urinary metabolite is measured by the Zimmerman Method using dinitrobenzene and yields a purple color?
  • Blood gas analysis QC is performed with how many levels and how often?
  • What color indicates the endpoint in the described precipitation/dye separation method?
  • Lipase levels in acute pancreatitis typically peak at about which time after onset?
  • Elevated AFP in maternal serum screening is most commonly associated with which condition?
  • Which method is used to separate bound T4 from its carrier?
  • What fraction of extracellular fluid is interstitial?
  • In the CPC-based calcium dye-binding assay, which additive prevents magnesium interference?
  • Which method is preferred for HbA1c determination?
  • Which carcinoplacental alkaline phosphatase isoenzyme is inhibited by phenylalanine?
  • Which of the following describes the four main classes of antiarrhythmic drugs?
  • In the Jaffe method, the kinetic improvement involves measuring absorbance at which?
  • Which test is primarily used for the diagnosis of diabetes?
  • The metabolic product marker for critical medical conditions is lactate above what value?
  • Which condition is explicitly described as salt-losing nephropathy contributing to hyponatremia?
  • If early screening in pregnancy is negative for GDM, when is glucose testing repeated?
  • For therapeutic drug monitoring, which methods are used for screening and confirmatory testing?
  • Which statement about random errors is true?
  • In Beer's Law A = a b c, which statement is correct?
  • In linear regression, the slope corresponds to which type of error?
  • When pH is not directly measured, which method is commonly used to estimate pH in buffer systems?
  • Beta-gamma bridging only on electrophoresis is most associated with which plasma component?
  • Which calcium-dye yields a violet color in the dye-binding approach?
  • Which accelerator is used in the Evelyn-Malloy method?
  • Which type of error affects precision?
  • What is the product formed in the Fiske Subbarow phosphate assay?
  • In a premenopausal woman, which estrogen is predominantly produced?
  • In a Lineweaver–Burk plot, a competitive inhibitor shows which change in Vmax and Km?
  • Which of the following is a ketose?
  • An oxytocin-producing tumor has been associated with which lung carcinoma type?
  • Which test differentiates neurogenic DI from nephrogenic DI?
  • In the description of chloride balance notation, what is listed as the 'Counter' ion?
  • Free PSA pattern relative to BPH and PC?
  • Which cell type secretes LH and FSH?
  • Which method is used to determine total protein concentration using dye binding?
  • Which acids are graded as 4 (Severe) in the laboratory severity scale?
  • The SI prefix for 10^18 is which of the following?
  • Which mineral acts as a cofactor for more than 300 enzymes?
  • Which markers are used to monitor breast cancer therapy?
  • In polarographic glucose oxidase assay, to prevent reformation of oxygen from hydrogen peroxide, which substances are added?
  • A monoclonal gammopathy curve on electrophoresis is characteristic of which disease?
  • Which equation expresses absorbance in terms of percent transmittance?
  • Which proliferation signal inhibitor inhibits dihydroorotate dehydrogenase?
  • Which option represents measures of central tendency?
  • Which statement best describes Borosilicate, Aluminosilicate, and High Silica glass in laboratory use?
  • What is measured by a pCO2 electrode as CO2 is present in the sample?
  • Partial immersion calibration pertains to which equipment?
  • Level of triglycerides that causes pancreatitis?
  • Which biomarker is commonly used to predict prognosis in AKI and is listed as an early predictor?
  • Which range defines Borderline High triglycerides?
  • In ethanol impairment, what is the second stage?
  • A patient specimen shows increased pCO2, decreased pO2, and decreased pH. This pattern is most consistent with:
  • Which instrument is typically used with colorimetric copper reduction methods such as Folin-Wu?
  • In flame photometry, which color corresponds to lithium emission?
  • Which test is associated with serotonin in the protocol?
  • Which biomarker is commonly used as an index of overall renal function?
  • The amylase:creatinine clearance ratio (SCUA) is calculated as which formula?
  • Storing ALP at 4°C has what effect on measured activity?
  • Which single enzyme is commonly used as a marker of hepatic injury?
  • In the Reitman Frankel transaminase assay, which reagent is used to form hydrazones?
  • GDM is screened during which gestational window?
  • ApoA4 main distribution and function?
  • Which enzyme pattern is associated with hepatocellular liver injury?
  • Which enzyme is not typically used as a secondary marker for obstructive jaundice?
  • Ostwald Folin transfer pipets are described as having which characteristic?
  • Which buffer is used specifically for the Bowers-McComb alkaline phosphatase method?
  • Which immunoassay type is homogeneous and relies on enzyme activity proportional to the analyte concentration?
  • Which support is traditionally used in paper chromatography?
  • Heparinized plasma cannot be used in which two assays?
  • In Menke's disease, copper levels are low due to inability to absorb copper, resulting in ceruloplasmin deficiency.
  • Which statement best describes Wilson's disease in terms of copper metabolism and ceruloplasmin?
  • Which compound is the other antiglycolytic agent besides sodium fluoride?
  • Which genes are considered indicators of hereditary cancer susceptibility in breast cancer risk assessment?
  • In the phosphate colorimetric assay, the reduced phosphomolybdate yields which color?
  • How do osmolarity and osmolality differ in their denominators?
  • Which of the following is a cause of high anion gap metabolic acidosis due to unmeasured anions?
  • Which method measures turbidity by blocking transmitted light?
  • Inhibin A provides feedback to inhibit which anterior pituitary hormone?
  • Which metabolite is produced by anaerobic glycolysis?
  • Absorbance formula as given?
  • Which hormones characterize the first, second, and third trimesters, respectively?
  • Which item is described as the most basic pipet?
  • Which option is NOT a method of amylase determination?
  • Which formula defines Negative Predictive Value?
  • Which hormone is higher in the late afternoon/PM due to diurnal variation?
  • Post-prandial ADA glucose goal is below what value?
  • In immunoassay instrumentation, which pairing correctly matches the detector type with the instrument commonly used to read it?
  • Which is described as the second vital buffer in the blood, acting as the principal buffer of red blood cells?
  • Increasing frequency of outliers in a data set is most closely associated with which statistical concept?
  • Normal range for serum osmolality is?
  • What is the standard deviation index (z score) formula used in the lab?
  • Hypermagnesemia can result from which condition?
  • Which lipoprotein has endogenous triglycerides as its major component?
  • What is the alternative for BUN enzymatic tests as sodium fluoride inhibits urease?
  • In pregnancy, beta-hCG reaches its peak around which week?
  • Which HDL-C determination method is considered the gold standard?
  • Sweat chloride analysis can be quantified by which two methods?
  • Which method is the method of choice for continuous monitoring of ACP?
  • Which of the following is NOT one of the three basic separation techniques?
  • Which posture change is associated with hemodilution?
  • Which statement correctly matches the metabolic actions of epinephrine and cortisol?
  • What is the ideal measurement time after collection for chemistry assays?
  • Cadmium exposure is associated with damage to which alveolar cells?
  • Which nondestructive method is used for determining organic compounds in lipoproteins, compared with destructive MS?
  • Which electrode is commonly used as a reference electrode in potentiometry?
  • Which analyte increases in the supine posture due to fluid shifts?
  • In laboratory workflow, which phase includes test selection and physician identification?
  • What is the bone crystal name in mineralized bone?
  • ACTH has which metabolic effects?
  • Which of the following is a B2 hepatic disease?
  • Which androgen is considered the most biologically active?
  • In the 1-step GDM diagnostic method using a 75 g load, what are the thresholds for fasting, 1-hour, and 2-hour glucose?
  • Which condition commonly causes secondary hyperparathyroidism?
  • Which trio of electrolytes is listed for Use no Water?
  • Whipple's triad of hypoglycemia includes which components?
  • Which of the following is an example of a centrifugal analyzer?
  • The solubility of a protein is lowest at its isoelectric point.
  • What is the free fraction percentage of T4 in plasma?
  • Which antigens are referred to as oncofetal antigens?
  • Which of the following is listed as an amphetamine-like substance?
  • In drug of abuse testing, which pairing is used for screening and confirmation?
  • Which drug is used to treat hyperuricemia by inhibiting xanthine oxidase?
  • Type 3c diabetes involves loss of pancreatic polypeptides.
  • What is the main action of oxytocin?
  • Which of the following are recognized contributors to potassium loss (LESS K)?
  • In slight hemolysis, which enzyme activity is most affected?
  • Best HUS marker since it is not an APR
  • What BAC defines legal intoxication limit?
  • In first-order enzyme kinetics, which statement is correct about limiting components?
  • Which pipet is described as the most used transfer pipet in the laboratory?
  • In Lean's application to clinical settings, 'Shorter STAT' refers to a desire to achieve what outcome?
  • Which organ primarily regulates extracellular potassium concentration?
  • Which tumor marker is associated with Lewis antigen status?
  • Which condition presents with elevated T3 but normal T4 (T3 thyrotoxicosis)?
  • For every 1°C increase in temperature, the multiplying factor for pO2 is:
  • Which statement identifies the least effective compensation for metabolic alkalosis?
  • Which condition is a water balance-related cause of hyponatremia, including SIADH?
  • In Step 1 of the two-step GDM screening, what 1-hour plasma glucose threshold prompts proceeding to Step 2?
  • In alkaline electrophoresis, proteins migrate toward which electrode?
  • Which vitamin is notably sensitive to light and should be protected from light during handling?
  • Which hormone is produced by the pineal gland?
  • In the presence of a competitive inhibitor, adding substrate will?
  • According to the material, which of the following is listed as a polar phospholipid?
  • Hyperprogesteronemia is associated with which menstrual outcome?
  • What is the most common cause of a high osmolal gap in clinical samples?
  • In a standard diagnostic 2x2 table, what do the terms True Positives and False Positives refer to?
  • A flipped LD1/LD2 ratio occurs in which scenario?
  • Lipase elevation in pancreatitis remains high for about how long before normalization?
  • Which drug requires whole blood for monitoring?
  • Which medication can cause hyperkalemia by decreasing renal potassium excretion?
  • What is the reference range for serum T4 in females?
  • What is the relationship between Thyroid Hormone Binding Ratio and Thyroxine-Binding Globulin?
  • Which marker best reflects hepatic synthetic function?
  • Which enzyme is the best marker for alcoholism?
  • Which of the following is an action of vitamin D?
  • Which instrument is used for the colorimetric enzymatic cholesterol assay?
  • Which are the metabolic functions attributed to Thyroxine in metabolism?
  • What is the reported toxic daily dose of lead?
  • Which method is typically used for calcium determination by titration?
  • Which cell type secretes ACTH?
  • In flame photometry, which color corresponds to calcium emission?
  • Amiodarone is classified as which type of antiarrhythmic?
  • According to the data, what is the approximate peak time window for Troponin I after myocardial injury?
  • What is the major cause of a shift in assay results?
  • Which placental hormone is primarily produced in the first trimester?
  • Which formula should be used to estimate osmolality when Na, Glucose, and BUN are expressed in mmol/L?
  • Which dye is used in calcium dye-binding method besides CPC?
  • What is the normal anion gap range when potassium is included?
  • Given magnesium’s role as a cofactor for over 300 enzymes, which statement best describes its impact?
  • Which body fluid does not reflect the same glucose concentration as blood?
  • Which protein is the primary carrier of retinol (Vitamin A) in serum?
  • What are the products of the initial reaction when beta-D-glucose is oxidized by glucose oxidase?
  • Which enzyme category uses ATP in its reaction?
  • Which two proteins serve as markers for CSF?
  • In Step 2 of the 2-step GDM test, how many of the four time-point thresholds must be exceeded to diagnose GDM?
  • Normal anion gap is influenced by which serum constituent according to the material?
  • What does HPLC stand for?
  • Which cell type is primarily responsible for the liver's metabolic and synthetic functions?
  • Cholesterol is described as a secondary test for two functions; which results are correct?
  • Which combination represents the 4Fs risk factors for liver disorders?
  • Which abnormal lipoprotein is described as sinking prebetalipoprotein?
  • Which chemical inhibitor inhibits Placental, Intestinal, Regan, and Nagao isoenzymes?
  • Which radioisotope is most commonly used in gamma counting and what is its approximate half-life?
  • In venous access procedures using transillumination, the distance to the vein is typically about how many inches?
  • In PCOS laboratory assessment, which parameter most directly reflects circulating free androgen activity?
  • Why have chemical copper reduction methods largely fallen out of use in glucose measurement?
  • Leucovorin rescue is used to rescue host cells when methotrexate is used.
  • Which sequence correctly describes the four steps of Beta Quantification?
  • CK-BB is primarily associated with which tissue type?
  • Which ion is listed as an inorganic anion activator (cofactor)?
  • In Homocystinuria, deficiency of which enzyme?
  • Which MS approach uses isotope dilution to quantify nonprotein nitrogens?
  • For a pH electrode, which is a valid option for the reference electrode tip?
  • In normal serum, what percentage of calcium is ionized?
  • Lp(a) density is similar to which lipoprotein?
  • Which material is used as the membrane for the sodium-selective ion electrode?
  • Oxyhemoglobin is corrected by determining its absorbance at which wavelength?
  • Which statement best describes autoantibody association in type 1 diabetes?
  • What instrument converts electrophoretic separation into quantitative data?
  • What is the formula for retention factor in chromatography?
  • Hemolysis can cause falsely elevated potassium in a sample because:
  • Niacin deficiency results in Pellagra. Which of the following best describes Pellagra?
  • Which type of luminescence is produced by biological luciferin-luciferase systems?
  • Mild elevation is defined as which range of ULN multiples?
  • In flame photometry, which color corresponds to copper emission?
  • Which pattern best describes primary hyperthyroidism in terms of TSH, FT4, TT3/TT4, and T3 uptake?
  • Which ALP isoenzyme resists heating at 65°C for 30 minutes?
  • Which MS technique is used for nonvolatile drugs?
  • Indirect calculation of LDL-C becomes inaccurate when TAG exceeds which value?
  • Which of the following is included as a measured analyte in a Basic Metabolic Panel?
  • What is the current reference method for triglycerides?
  • What is the key rationale for using a 2-hour OGTT in diabetes screening?
  • What is the listed critical range for sodium?
  • In the enzymatic method for non-protein nitrogen, most components are measured by a decrease in absorbance at which wavelength?
  • Which element has an atomic weight approximately 36?
  • The Kjeldahl method estimates protein content by measuring which element?
  • Which of the following is a correct statement about automatic micropipettors?
  • Which elements are classic examples of water-reactive chemicals?
  • Surface immersion calibration applies to which equipment?
  • An alpha-1 flat curve on electrophoresis is associated with which condition?
  • Elevation of alkaline phosphatase in bone tumors is typically how many times ULN?
  • Which of the following is NOT considered a DOWNTIME waste?
  • During pregnancy, which estrogen is primarily produced as a joint effort of mother and fetus, with fetal DHEAS needed by the placenta?
  • Which infection decreases CRP?
  • Which statistic is used to confirm precision?
  • Which chromatography form uses a stationary phase in a column?
  • Which is an acute complication of Type 1 diabetes mellitus?
  • Polarography and amperometry differ in that polarography measures current at which condition?
  • Albumin concentration is commonly measured by which dye-binding method?
  • AST and ALT belong to which category in liver function testing?
  • Which of the following is NOT listed as one of the two most common interferences in hexokinase glucose measurement?
  • Which pairing correctly matches triglyceride appearance with approximate level?
  • What is the recommended fasting duration for triglycerides and lipoproteins?
  • Tangier disease is associated with ABCA1 mutation and very low HDL. Which condition is this?
  • Which copper reduction method is Benedict's variant that uses stabilizers such as citrate or tartrate?
  • When a pH value is not given, which measurements are used to determine acidosis or alkalosis?
  • Which detector is commonly used in GC/HPLC?
  • Peak plasma concentration timing for digoxin after oral administration is typically about how many hours?
  • What is the most common visible light source?
  • Methotrexate is an antineoplastic agent that destroys thymine.
  • Procalcitonin is increased in bacterial infection within which time frame?
  • The expression for osmotic concentration relative to a reference is called?
  • Atomic absorption spectroscopy (AAS) features which of the following?
  • What color does the oxidized chromogen quinoneimine impart in Trinder-type assays?
  • HbA1c diagnostic criterion requires the value to be met on how many occasions?
  • Which sequence correctly orders reagent grades from purest to least pure?
  • What is the standard technique for pipetting aqueous solutions?
  • Which medium is used for charge-based separation in electrophoresis?
  • Intracellularly, which LD isoenzyme is more abundant?
  • Rank the ALP isoenzymes by heat stability from most to least stable.
  • Which chemical inhibitor is specific for the Bone isoenzyme?
  • Which enzyme marker is most commonly used to indicate hepatobiliary obstruction?
  • In hyperglycemia, the measured serum sodium concentration decreases by approximately how much for every 100 mg/dL increase in plasma glucose?
  • Which method uses UV-spectrophotometry for transaminase determination?
  • Which metric is defined as TP divided by (TP plus FN)?
  • A total cholesterol value of 230 mg/dL falls into which category?
  • Inverted A:G ratio is significant in which condition?
  • Which thyroid cells produce T3 and T4?
  • Which of the following is listed as an additional hypernatremia cause?
  • In flame photometry, which color corresponds to sodium emission?
  • Coenzymes that are tightly bound to the enzyme are called?
  • Which lipase determination method measures the rate of clearing by turbidity?
  • In electrophoresis, B-VLDL travels with which lipoprotein?
  • Which element has an atomic weight of about 40?
  • In this material, the F-test is defined as the ratio of which two statistics?
  • CNS stimulants vs depressants: which pairing is correct?
  • In flame photometry, which color corresponds to potassium emission?
  • Which mnemonic is associated with the random error concept?
  • When a standard curve has good linearity, what does y represent?
  • Niacin deficiency presents with Pellagra. Which vitamin is Niacin?
  • Which glass type is specifically designed to protect samples from light while providing reasonable thermal stability?
  • Criggler-Najjar Type 1 is characterized by which UDPGT deficiency?
  • Hypernatremia associated with urine osmolality less than 300 mOsm/kg is most consistent with which condition?
  • Fuller's Earth adsorbent is composed of which silicate?
  • Which accelerator is used in the Jendrassik Groff method?
  • Which of the following is a calcineurin inhibitor?
  • A routine lipid profile consists of which four components?
  • Which of the following is NOT a core component of lipoproteins?
  • In Kjeldahl nitrogen determination, which two reagents are essential for the digestion step?
  • Whole blood glucose concentration is lower than plasma by what percent?
  • In the direct pathway of HDL returning cholesterol to the liver, which receptor mediates uptake of cholesteryl esters on hepatocytes?
  • In a pO2 sensor, what are the correct materials for the cathode and anode?
  • What is the desirable LDL:HDL ratio?
  • The relationship between cholesterolemia and thyroid function is generally described as:
  • Which plastic is used for graduated cylinders and centrifuge tubes?
  • Which two methods are used for transaminase determination?
  • Dopamine, acting as a prolactin-inhibiting factor, inhibits the release of which hormone?
  • What is the main difference between horizontal and fixed-angle centrifuge rotors?
  • In atomic absorption spectroscopy, which categories of interference are recognized?
  • In the AST determination using the MDH step, which enzyme is used?
  • Which of the following is a laboratory method used to measure magnesium?
  • Which set of reagents correctly lists all reagents used in the Biuret method?
  • Which stimulant is commonly used to treat narcolepsy?
  • What is the active metabolite of procainamide?
  • Which enzyme is commonly elevated in acute hepatitis?
  • Plastic tubing is commonly made from which polymer?
  • Which Fredrickson Type corresponds to Familial Dysbetalipoproteinemia (IDL, B-VLDL)?
  • Fructosamine measurement is unreliable in hypoalbuminemia when albumin is at or below what level (in g/dL)?
  • What is the normal RAIU uptake at 24 hours?
  • Which protein is the primary carrier for basic drugs in plasma?
  • Which blank measures the absorbance of the sample?
  • Which group of antibiotics is listed?
  • Enzyme inactivation tends to occur at which temperature range?
  • Type 1b is Fulminant Type 1 Diabetes, characterized by no autoantibodies.
  • Which protein binds PSA and is increased in Alzheimer's disease?
  • Which lyase is clinically significant?
  • What type of study is used to verify the accuracy of a new analytical method against a reference method?
  • Which test assesses variability between two groups to evaluate precision?
  • Radio waves have wavelengths greater than 1 centimeter.
  • Which is the most potent estrogen?
  • Deficiency of alpha-1 antitrypsin is associated with mutation in which gene?
  • A buffer is a mixture of which components?
  • Which group of elements has approximate atomic weights of 10, 12, 14, 16, and 18?
  • Poppy plants are the natural source of which class of abused drugs?
  • Which two instruments are used to quantify by precipitation of immune complexes?
  • Which dye-binding reagent is used for total protein measurement?
  • Which element is considered a glucose tolerance factor in type 2 diabetes mellitus?
  • Tarui disease is due to deficiency of which enzyme?
  • Estimated total blood volume for a 70 kg adult is approximately?
  • Amylase normalization in acute pancreatitis occurs typically within which time frame?
  • Prostaglandins are derived from which parent molecule?
  • Which form of vitamin D is considered inactive?
  • Which adrenal cortex zone primarily secretes cortisol?
  • What term describes the drug concentration range between the minimum effective concentration and the minimum toxic concentration?
  • Which of the following are optical methods for protein measurement?
  • In the triple marker screen, which pattern is characteristic of Trisomy 21?
  • What is the relationship between triglyceride levels and thyroidism?
  • Potassium concentration is approximately how many times higher inside cells than in extracellular fluid?
  • What is the most common point-of-care testing (POCT)?
  • Which ratio is used to test for patency of the liver?
  • Which two analgesics listed do not require therapeutic drug monitoring?
  • Which condition is NOT associated with elevated ammonia levels?
  • Which buffer is considered the principal buffer of intracellular fluids?
  • Electroendosmosis causes the gamma globulin band to migrate toward which electrode during electrophoresis?
  • According to the critical values list, what is the critical glucose range?
  • Absorbance accuracy in spectrophotometry is checked using which combination?
  • Clark-Collip oxalic acid precipitation is used to precipitate calcium with which reagent?
  • How long can serum be stored at room temperature before analysis?
  • Alkaline phosphatase (ALP) optimum pH is typically around:
  • The Renal Panel is BMP-like but with which specific changes?
  • What happens to glucose concentration if a serum sample is stored at room temperature?
  • CK is a _____ (protein unit).
  • Which enzyme tends to rise earliest in pancreatitis?
  • GDM converts to DM within 10 years in approximately what percent?
  • Which laboratory parameter most directly indicates decreased hepatic synthetic function in cirrhosis?
  • Panic pO2 value is at or below which threshold?
  • What is the recommended lancet length for newborns?
  • Which lab pattern describes secondary hyperthyroidism (all values elevated)?
  • Dementia associated with dialysis is linked to which metal?
  • What is the most important clinical application of electrophoresis?
  • Which of the following specimens is preferred for osmolality measurements?
  • In spectrophotometry, what is the purpose of a reagent blank?
  • Which thyroid hormone is considered the inactive form?
  • Delta bilirubin with black granules (lipofuscin) is characteristic of which disorder?
  • Which statements best describe two markers for congestive heart failure used clinically?
  • Which parameter represents proportional systematic error?
  • The Renal Panel is BMP-like but with which changes?
  • Which molecule acts as the acetyl donor entering the Krebs cycle?
  • What is the approximate half-life of cocaine?
  • Which test is used as a confirmatory test for adrenal insufficiency?
  • During the 2-hour OGTT, how many blood draws are typically performed?
  • Among the diurnal variation list, which hormone is highest in the morning?
  • ApoA2 main distribution and function?
  • Which term describes the migration of small ions during electrophoresis?
  • In enzymatic creatinine determination, the initial reaction with creatininase produces which compound?
  • Which coenzyme is required for AST and ALT transaminase reactions?
  • Venous blood glucose is typically how much lower than capillary or arterial blood?
  • Electrophoretic mobility: which lipoprotein shows alpha mobility?
  • What is the normal serum osmolality range (in mOsm/kg)?
  • A CEA value greater than what threshold is typically associated with malignancy?
  • Which of the following are two actions of human placental lactogen (hPL)?
  • In a Lineweaver–Burk plot, a non-competitive inhibitor shows which change in Vmax and Km?
  • What is the reference range for serum amylase?
  • How many observations are required when calculating the standard deviation in the quality control context described?
  • Which factor can cause a false positive urine bhCG result?
  • Which is a gamma globulin protein?
  • Which enzyme is NOT part of the enzymatic cholesterol method?
  • Which of the following is considered the best single criterion for diagnosing diabetes by ADA?
  • Which colorimetric method is used to detect peptide bonds in proteins?
  • Which enzyme is a transferase used as a marker for liver disease?
  • Physical properties that depend on relative concentration but not identity are called?
  • Which gas is NOT listed as a mobile phase in the source material for gas chromatography?
  • HbA1c level that indicates poor glycemic control is greater than what percent?
  • Which regulator is released in response to increased plasma osmolality and acts on the kidneys to conserve water?
  • Which technique separates proteins by migration in a pH gradient?
  • Compared with serum or plasma, whole blood glucose is typically lower by about what percentage?
  • Which molecule is used as the membrane for the potassium-selective ion electrode?
  • What is the CFU/mL threshold for Type 1 reagent water?
  • Which glass releases alkali as described in the material?
  • If the hydrogen ion concentration [H+] is 1 x 10^-3 M, what is the pH?
  • Which of the following is NOT a type of luminescence listed in the material?
  • Which substance is most commonly abused worldwide?
  • LpX is associated with deficiency of which enzyme?
  • Which enzyme reduces oxaloacetate to malate using NADH in the pathway?
  • Which Aldolase isoenzyme is found mainly in white blood cells, liver, and kidney?
  • Positive displacement micropipettors are described as using which configuration?
  • In an air displacement micropipettor, the tip is typically used with which piston configuration?
  • Which lipoprotein has the lowest triglyceride content?
  • In the Ferric Reduction method, what are the colors of the reagents before and after reaction with glucose?
  • Which protein is an example of a quaternary structure?
  • Fluorometer sensitivity is how many times higher than that of a spectrophotometer?
  • Among lipoproteins, which carries the most triglycerides?
  • Vancomycin administration may cause which syndrome?
  • Which condition is typically associated with elevated T3 and T4?
  • For every 1°C increase in temperature, the multiplying factor for pCO2 is:
  • Which test is used to confirm hypoglycemia in the diagnostic workup?
  • Subclinical hyperthyroidism is best described by which pattern of TSH and FT4/TT3/TT4?
  • Prolonged storage of a specimen tends to cause which primary change?
  • Renal threshold for sodium excretion is typically between which values?
  • Which test is used to assess stray light in spectrophotometers?
  • If the pH of a solution is higher than a protein's isoelectric point, the protein will carry what net charge?
  • Which of the following is a mineral electrolyte commonly measured in clinical chemistry?
  • In refractometry, how much sample is required?
  • Which mnemonic stands for 'Sodium in, potassium out'?
  • Severe diarrhea is associated with chloride levels that are:
  • If data are skewed, which measure of central tendency should be used?
  • Which pattern best describes the immediate/acute-phase response on electrophoresis?
  • Increasing the concentration of heparin in an ABG sample tends to cause which combination of effects?
  • Pronounced elevation is defined as how many times ULN?
  • What color is produced by the Jaffe reaction when creatinine reacts with the Jaffe reagent?
  • What is the percentage distribution of beta-D-glucose and alpha-D-glucose reported in this material?
  • Which of the following is a measure of dispersion?
  • Density of B-VLDL is similar to which lipoprotein?
  • TD pipets are calibrated with which liquid?
  • Which method is used as the reference method for enzymatic glucose measurement because it does not use hexokinase?
  • The low-dose dexamethasone suppression test is used to distinguish Cushing's syndrome from which group?
  • What is the most common cause of secondary adrenal insufficiency?
  • LDX corresponds to an LD isoenzyme found in which tissue?
  • What are the three major electrolytes for osmolality (distinct from osmolarity)?
  • Which expression represents the FTI formula?
  • In advanced liver fibrosis where hepatocytes are largely destroyed, AST, ALT, and LD levels are typically:
  • In CLSI terminology, Type III water is used as Autoclave wash water.
  • In females, FSH primarily stimulates which processes?
  • Which combination of reagents is used in the Kjeldahl digestion step for protein analysis?
  • In the Wacker/Forward LD assay, which conversion occurs?
  • Elevated 17-hydroxyprogesterone is most characteristic of deficiency of which enzyme in congenital adrenal hyperplasia?
  • Magnesium concentration in red blood cells is approximately how many times higher than in plasma?
  • What is the stated exponent of the meter?
  • In a basal fasting state, which analyte is commonly measured to assess carbohydrate metabolism?
  • Which is described as the most important component of HDL?
  • Which plastic is used for alkaline storage?
  • The Albanese Lein colorimetric method is used to measure which analyte?
  • The nitrogen content of protein is approximately what percent?
  • What is the chief female androgen?
  • The most common cause of hyperbilirubinemia is
  • In the Hexokinase enzymatic glucose method, what activator is commonly used?
  • Which of the following is a line source?
  • Which drug is hepatotoxic?
  • For individuals aged 20-29, what is the High Risk cut-off for total cholesterol?
  • Which hormone is highest in the morning due to diurnal variation?
  • Dry excess anticoagulant effect leads to which change?
  • In the reference method described, what is the substrate used?
  • Which diagnostic test is used for ADH deficiency?
  • Which protein is an acute-phase reactant?
  • Type 1 diabetes mellitus is defined as IDDM with more than one autoantibody.
  • If a solution contains 3 equivalents of solute per liter, the normality is
  • All approaches to automation are capable of which function?
  • Severe burns are listed as a hyponatremia cause via which mechanism?
  • A monoclonal gammopathy curve on electrophoresis most strongly suggests which disease?
  • Bisalbuminemia and analbuminemia are inherited in which pattern?
  • Which chloride determination method uses coulometry-amperometry?
  • What is the critical total bilirubin value listed?
  • Which set represents hepatocellular injury markers?
  • NDML stands for neonatal diabetes mellitus.
  • What is the preferred specimen for most drug assays?
  • Type 3b diabetes involves defects in the exocrine pancreas.
  • Which systems regulate water reabsorption in the kidney?
  • Which of the following is NOT typically associated with persistent hyperglycemia?
  • In colligative property measurements, the freezing point changes by approximately how many degrees Celsius per osmole increase of solute?
  • Which antibody is most characteristic of Graves disease?
  • In linear regression, the y-intercept corresponds to which type of error?
  • Type I and Type II water are used as which type of water in CLSI terms?
  • In a calibration context, which statement best represents the relationship between unknown and standard samples?
  • Which of the following is NOT a hallucinogen?
  • Which instrument is used for the enzymatic ammonia determination?
  • Which enzyme is commonly elevated with skeletal muscle activity?
  • Elevated DHEA is associated with deficiency of which enzyme in congenital adrenal hyperplasia?
  • What is the free fraction percentage of T3 in plasma?
  • Which conditions can cause high plasma osmolality, contributing to hypernatremia?
  • Which substance is used as the substrate when performing amylase activity assays?
  • After refrigeration, which LD isoenzymes remain active?
  • In the context described, which parameter is the ion-selective electrode reading used to derive bicarbonate for the anion gap calculation?
  • Which complication is listed as the most common in phlebotomy?
  • Which two agents are listed as bronchodilators?
  • If blanking cannot be performed, which approach is used?
  • Xanthine oxidase catalyzes the conversion of purines into which compound?
  • SST and PST can cause decreases in which two drugs?
  • How is molarity defined?
  • What is another name for fluorometry?
  • Which test is used to assess long-term glycemic control?
  • In a thyroid follicle, where are the follicular cells located relative to the colloid?
  • Which technique is the gold standard for drug testing?
  • Which immunoassay for thyroxine testing is indirectly proportional?
  • Which drug is a second-generation antiepileptic that does not require therapeutic drug monitoring?
  • Which cell type secretes growth hormone?
  • Bicarbonate accounts for approximately what percentage of total CO2 in blood?
  • Which instrument is used to measure monovalent ions via photometric techniques?
  • Which two enzymes help distinguish bone from liver disease when ALP is increased?
  • Which hormone acts as a negative feedback signal to inhibit growth hormone secretion?
  • Which BAC range corresponds to death?
  • What is the electrophoresis order of ALP isoenzymes from most anodic to least anodic?
  • Which drug is classified as a long-acting barbiturate?
  • Which Fredrickson type carries the highest cardiac risk?
  • Normal BUN-to-creatinine ratio is typically within which range?
  • What is the typical fixed-angle range used in fixed-angle centrifuges?
  • Creatinine constitutes what percent of NPNs?
  • What is the most common source of loss of linearity in a spectrophotometer?
  • Nagao isoenzyme is associated with which cancer?
  • Which enzyme hydrolyzes triglycerides in circulating lipoproteins?
  • Which value represents the reference range for total bilirubin?
  • Which method among the listed calcium measurement approaches uses atomic absorption spectroscopy?
  • Hypernatremia caused by increased water loss can be due to which condition?
  • Myoglobin is a negative predictor of acute myocardial infarction within how many hours?
  • Which term describes proteins that contain a non-protein prosthetic group?
  • Hypernatremia caused by decreased water intake is seen in which groups?
  • Which statement correctly pairs primary hypergonadism with its typical cause?
  • Which of the following is a cause of a high osmolal gap?
  • In the correlation of results, which expression defines the rate with respect to antigen concentration?
  • What is the molecular weight of alpha-2 macroglobulin?
  • Which condition is described as a hyponatremia cause associated with hypoaldosteronism?
  • Molality is defined as
  • Which method is described as expensive and sensitive for urea determination?
  • Which cell type of the anterior pituitary gland secretes prolactin?
  • What term describes a uniform mixture of solute and solvent?
  • The most abundant lipids class, according to the material, is which?
  • Which hormones are said to perform gluconeogenesis and glycogenolysis?
  • Which amino acid is listed as the most abundant protein in the body and used in many processes?
  • In questions, a highly sensitive and specific method is referred to as which type of method?
  • In spill cleanup, what is the first step?
  • What is the standard glucose load for the 2-hour OGTT in adults?
  • Midnight salivary cortisol in primary hypercortisolism is typically what?
  • In the Fiske Subbarow phosphate assay, the UV measurement is performed at which wavelength?
  • In the equation y = mx + b, what does m denote?
  • Which of the following is an example of a TD pipette?
  • Which term describes minimal complexity of instrumentation?
  • Tolbutamide is administered by which route in this context?
  • Which lipoprotein is the most atherogenic?
  • Renal or post-renal azotemia is suggested by which pattern of BUN and creatinine?
  • Bronze diabetes is caused by deposition of which element?
  • Highest elevation of LD is observed in which condition?
  • Which markers are predominantly elevated in biliary obstruction?
  • What is the critical pH range listed in the blood gas critical values?
  • Parkinson's disease has been linked to exposure to which trace element?
  • Which reagent is used in the Zimmerman test for 17-ketosteroids?
  • In beta quantification, ultracentrifugation is used to remove which lipoproteins?
  • Which method is NOT used for apolipoprotein assays?
  • Is cholesterol an energy source?
  • An SDI value of 2.5 indicates poor performance.
  • Which of the following is NOT a protease inhibitor?
  • For absence (petit mal) seizures, which drug is preferred?
  • In separation techniques, electrophoresis separates primarily by which property?
  • After heating at 56°C for 10 minutes, what are the expected residual activities for bone and liver ALP?
  • Which of the following is NOT listed as an indication that calibration is needed?
  • Among proteins, which lipoprotein is most abundant?
  • Levels of control are described as which categories?
  • In the Modified Abell-Kendal method for serum cholesterol, what modification is used compared to the standard LB method?
  • Which of the following is used in the evaluation of pheochromocytoma?
  • Uric acid comprises what percent of non-protein nitrogen (NPN)?
  • Which of the following is not used in the evaluation of pheochromocytoma?
  • Bilirubin oxidase method measures decreased absorbance at which wavelength range?
  • Bioavailability is defined as the ratio of drug absorbed from the administered dose.
  • What is the reference method and substrate for ACP measurement?
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